INT181998

Context Info Confidence 0.07 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.98 Pain Relevance 0.27

extracellular matrix organization (TNFRSF11B) cytoplasm (CTSK) signal transduction (TNFRSF11B) extracellular space (CTSK) peptidase activity (CTSK) extracellular region (TNFRSF11B)

TNFRSF11B (Homo sapiens) CTSK (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 28 90.80 Inflammation 5 75.92 Rheumatism 1 37.60 methotrexate 2 13.52 Leflunomide 3 11.44 cytokine 1 5.00 Pain 1 5.00 visual analogue scale 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 1 99.72 Metastasis 3 98.96 Hypercalcemia 6 98.80 Osteopetrosis 1 94.56 Targeted Disruption 1 93.36 Congenital Anomalies 2 92.16 Rheumatoid Arthritis 28 90.80 Acro-osteolysis 1 90.48 Growth Problems 1 89.84 Pycnodysostosis 1 86.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Osteoprotegerin has been shown to inhibit the expression of cathepsin K, the main enzyme involved in bone resorption.

Osteoprotegerin Negative_regulation (inhibit) of Gene_expression (expression) of cathepsin K associated with hypercalcemia

1) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 1.98 Pain Relevance 0.27

General Comments

This test has worked.