INT182010

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.13
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b)
extracellular matrix organization (Tnfrsf11b)
Anatomy Link Frequency
osteoclasts 2
Tnfrsf11b (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 64 97.56 Very High Very High Very High
rheumatoid arthritis 66 90.00 High High
adenocard 2 68.28 Quite High
Inflammation 4 61.32 Quite High
methotrexate 2 56.08 Quite High
antagonist 6 50.00 Quite Low
cytokine 6 49.04 Quite Low
Pain 4 46.48 Quite Low
Serotonin 14 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 20 100.00 Very High Very High Very High
Rheumatoid Arthritis 66 90.00 High High
Disease 24 84.64 Quite High
INFLAMMATION 8 61.32 Quite High
Synovitis 2 59.88 Quite High
Bone Cancer 12 54.60 Quite High
Cancer 16 50.00 Quite Low
Necrosis 8 50.00 Quite Low
Pain 4 46.48 Quite Low
Frailty 2 38.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spearman's correlation was used to determine a relationship between the changes in IL-6 and OPG levels and those of TNF-?
Regulation (changes) of OPG
1) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.27 Pain Relevance 0.25
Finally, we looked for a possible link between changes in OPG and IL-6 levels and the rate of clinical improvement during infliximab treatment.


Spec (possible) Regulation (changes) of OPG associated with infliximab
2) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.44 Pain Relevance 0.34
In addition, osteoprotegerin (OPG), a molecule produced by cells of the osteoblast lineage that inhibits activation of osteoclasts [113], is a direct transcriptional target for ?
Regulation (target) of osteoprotegerin in osteoclasts associated with osteoporosis
3) Confidence 0.11 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.21 Pain Relevance 0.03
In addition, osteoprotegerin (OPG), a molecule produced by cells of the osteoblast lineage that inhibits activation of osteoclasts [113], is a direct transcriptional target for ?
Regulation (target) of OPG in osteoclasts associated with osteoporosis
4) Confidence 0.11 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.21 Pain Relevance 0.03

General Comments

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