INT182010

Context Info Confidence 0.18 First Reported 2005 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 4 Disease Relevance 1.13 Pain Relevance 0.67

signal transduction (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)

Anatomy Link Frequency osteoclasts 2 Tnfrsf11b (Mus musculus)

Pain Link Frequency Relevance Heat Infliximab 64 97.56 rheumatoid arthritis 66 90.00 adenocard 2 68.28 Inflammation 4 61.32 methotrexate 2 56.08 antagonist 6 50.00 cytokine 6 49.04 Pain 4 46.48 Serotonin 14 5.00 cINOD 4 5.00

Disease Link Frequency Relevance Heat Osteoporosis 20 100.00 Rheumatoid Arthritis 66 90.00 Disease 24 84.64 INFLAMMATION 8 61.32 Synovitis 2 59.88 Bone Cancer 12 54.60 Cancer 16 50.00 Necrosis 8 50.00 Pain 4 46.48 Frailty 2 38.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Spearman's correlation was used to determine a relationship between the changes in IL-6 and OPG levels and those of TNF-?

Regulation (changes) of OPG

1) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.27 Pain Relevance 0.25

Finally, we looked for a possible link between changes in OPG and IL-6 levels and the rate of clinical improvement during infliximab treatment.

Spec (possible) Regulation (changes) of OPG associated with infliximab

2) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.44 Pain Relevance 0.34

In addition, osteoprotegerin (OPG), a molecule produced by cells of the osteoblast lineage that inhibits activation of osteoclasts [113], is a direct transcriptional target for ?

Regulation (target) of osteoprotegerin in osteoclasts associated with osteoporosis

3) Confidence 0.11 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.21 Pain Relevance 0.03

In addition, osteoprotegerin (OPG), a molecule produced by cells of the osteoblast lineage that inhibits activation of osteoclasts [113], is a direct transcriptional target for ?

Regulation (target) of OPG in osteoclasts associated with osteoporosis

4) Confidence 0.11 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.21 Pain Relevance 0.03

General Comments

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