INT182021

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Il6) extracellular region (TNF, Il6) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
monocytes 1
TNF (Homo sapiens)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 32 99.36 Very High Very High Very High
cytokine 28 86.08 High High
rheumatoid arthritis 33 83.36 Quite High
Potency 1 77.48 Quite High
cINOD 10 72.28 Quite High
COX-2 inhibitor 6 67.28 Quite High
Inflammatory stimuli 1 59.36 Quite High
Inflammation 11 50.72 Quite High
Pain 3 28.32 Quite Low
antagonist 2 5.12 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 33 83.36 Quite High
INFLAMMATION 17 71.72 Quite High
Sepsis 51 69.68 Quite High
Hemorrhage 3 69.56 Quite High
Toxicity 2 69.04 Quite High
Necrosis 7 55.00 Quite High
Cancer 8 54.64 Quite High
Critical Illness 2 51.12 Quite High
Stress 1 49.92 Quite Low
Infection 5 46.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
alone stimulates IL-6 production and this effect can be abrogated by first incubating TNF-?
TNF Binding (abrogated) of IL-6
1) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.14 Pain Relevance 0.12
It also exhibited marked inhibitory properties on endotoxin-induced IL-6 formation in THP1 monocytes, with less activity on TNF and IL-1?.
TNF Binding (formation) of IL-6 in monocytes
2) Confidence 0.02 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 0.60 Pain Relevance 0.41

General Comments

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