INT182022

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.56
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, Tnfrsf11b) extracellular region (TNF, Tnfrsf11b) extracellular matrix organization (TNF, Tnfrsf11b)
extracellular space (TNF) proteinaceous extracellular matrix (Tnfrsf11b) plasma membrane (TNF)
TNF (Homo sapiens)
Tnfrsf11b (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 96 99.78 Very High Very High Very High
rheumatoid arthritis 99 99.68 Very High Very High Very High
Inflammation 6 65.88 Quite High
cytokine 9 53.60 Quite High
methotrexate 3 50.40 Quite High
Pain 3 40.80 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 99 99.68 Very High Very High Very High
Necrosis 12 94.76 High High
Cancer 12 94.40 High High
Disease 15 78.96 Quite High
INFLAMMATION 6 65.88 Quite High
Synovitis 3 64.44 Quite High
Chronic Disease 3 41.56 Quite Low
Pain 3 40.80 Quite Low
Frailty 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With regard to IL-6, addition of infliximab inhibited OPG production induced by TNF-?
TNF Positive_regulation (induced) of Gene_expression (production) of OPG associated with infliximab
1) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.23 Pain Relevance 0.27
Therefore, a bioassay was developed using the properties of synoviocytes to produce IL-6 and osteoprotegerin (OPG) in response to TNF-?
TNF Positive_regulation (response) of Gene_expression (produce) of osteoprotegerin
2) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.55 Pain Relevance 0.36
The bioassay is based on the induction of IL-6 and osteoprotegerin (OPG) production by synoviocytes in response to TNF-?.
TNF Positive_regulation (response) of Gene_expression (production) of OPG
3) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064892 Disease Relevance 0.79 Pain Relevance 0.34

General Comments

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