INT182031

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 38
Total Number 44
Disease Relevance 46.37
Pain Relevance 19.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 4
cartilage 2
neutrophils 2
B-lymphocytes 1
lymphocytes 1
Cia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 4405 100.00 Very High Very High Very High
cytokine 753 100.00 Very High Very High Very High
agonist 135 99.84 Very High Very High Very High
Inflammation 911 99.52 Very High Very High Very High
metalloproteinase 28 99.48 Very High Very High Very High
rheumatoid arthritis 1767 99.12 Very High Very High Very High
chemokine 190 97.44 Very High Very High Very High
Inflammatory response 113 97.36 Very High Very High Very High
anesthesia 8 95.60 Very High Very High Very High
ketamine 3 92.32 High High
Disease Link Frequency Relevance Heat
Arthritis 4581 100.00 Very High Very High Very High
Experimental Arthritis 87 100.00 Very High Very High Very High
Arthropathy 96 99.84 Very High Very High Very High
Disease 1045 99.74 Very High Very High Very High
INFLAMMATION 965 99.52 Very High Very High Very High
Sprains And Strains 94 99.48 Very High Very High Very High
Immunization 321 99.36 Very High Very High Very High
Rheumatoid Arthritis 1800 99.12 Very High Very High Very High
Pressure And Volume Under Development 281 98.24 Very High Very High Very High
Autoimmune Disease 299 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When evaluating the value of serum markers, MMP-3 was found to be highly indicative of all the features of CIA, including inflammation, cartilage destruction and bone erosion.
Gene_expression (indicative) of CIA in cartilage associated with inflammation, metalloproteinase and arthritis
1) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.15 Pain Relevance 0.69
levels in pre-CIA onset and chronic-CIA mice, showing that selectins may also regulate chemokine production.
Gene_expression (onset) of CIA associated with chemokine and arthritis
2) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.95 Pain Relevance 0.46
Consistent with the pre-CIA and early-CIA analyses, no significant concentrations of TNF-?
Spec (analyses) Gene_expression (analyses) of CIA associated with arthritis
3) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.81 Pain Relevance 0.54
Consequently, we investigated the hypothesis that mice that lack selectin molecules develop accelerated CIA as a result of altered cytokine expression.
Gene_expression (expression) of CIA associated with cytokine and arthritis
4) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.70 Pain Relevance 0.47
Consistent with the pre-CIA and early-CIA analyses, no significant concentrations of TNF-?
Spec (analyses) Gene_expression (analyses) of CIA associated with arthritis
5) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.81 Pain Relevance 0.54
CIA induction and scoring for CIA development
Gene_expression (development) of CIA associated with arthritis
6) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.74 Pain Relevance 0.22
production in pre-CIA onset, post-CIA onset, and chronic-CIA E-/P-selectin mutant mice (Fig. 3).


Gene_expression (production) of CIA associated with arthritis
7) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.74 Pain Relevance 0.53
is present in CIA but is expressed only transiently before the onset of disease.
Gene_expression (present) of CIA associated with disease and arthritis
8) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.20 Pain Relevance 0.44
While our results in the mouse CIA model suggest a role of B7-H4 in pathogenesis of CIA, one should be cautious because the CIA model does not mimic human RA in all aspects, and it remains to be tested whether sH4 participates in the development of human RA.
Gene_expression (model) of CIA associated with rheumatoid arthritis and arthritis
9) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.63 Pain Relevance 0.58
In addition, this method is also effective in suppressing progression of CIA.
Gene_expression (progression) of CIA associated with arthritis
10) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.93 Pain Relevance 0.35
and IL-17, two major cytokines responsible for CIA progression, also increased significantly in the cultures (Figure 2F).
Gene_expression (progression) of CIA associated with arthritis and cytokine
11) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.81 Pain Relevance 0.32
Suppression of CIA by Agonist B7-H4
Gene_expression (Suppression) of CIA associated with agonist and arthritis
12) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.77 Pain Relevance 0.46
After hydrodynamic injection with control vector, and 80% of mice developed disease on day 49, a result similar to CIA mice without plasmid injection (unpublished data), indicating hydrodynamic injection itself does not significantly change the course of CIA progression.
Gene_expression (progression) of CIA associated with disease and arthritis
13) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.98 Pain Relevance 0.21
Therefore, we could not establish a correlation between endogenous sH4 and CIA progression in this model.
Gene_expression (progression) of CIA associated with arthritis
14) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.08 Pain Relevance 0.27
The effect of B7-H4Ig on preventing the progression of CIA was first tested.
Gene_expression (progression) of CIA associated with arthritis
15) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.66 Pain Relevance 0.36
To help address this issue, we applied mouse CIA models, a well characterized mouse model for human RA, to further address if sH4 could promote disease activity.
Gene_expression (models) of CIA associated with rheumatoid arthritis, disease and arthritis
16) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.23 Pain Relevance 0.35
While our results in the mouse CIA model suggest a role of B7-H4 in pathogenesis of CIA, one should be cautious because the CIA model does not mimic human RA in all aspects, and it remains to be tested whether sH4 participates in the development of human RA.
Gene_expression (pathogenesis) of CIA associated with rheumatoid arthritis and arthritis
17) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.69 Pain Relevance 0.58
Our result supports the hypothesis that neutrophils are required for sH4-mediated exacerbation of CIA.
Gene_expression (exacerbation) of CIA in neutrophils associated with arthritis
18) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.05 Pain Relevance 0.43
Using a hydrodynamic injection method to express B7-H4 plasmid in vivo, we demonstrated that expression of sH4 promotes autoimmune responses, leading to progression of CIA, and similar results are also observed in B7-H4–deficient mice.
Gene_expression (progression) of CIA associated with arthritis
19) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.53 Pain Relevance 0.49
We first examined the effect of neutrophil depletion in sH4-mediated exacerbation of CIA.
Gene_expression (exacerbation) of CIA in neutrophil associated with arthritis
20) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.15 Pain Relevance 0.36

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