INT182034

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 8.76
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
T-cell 2
joints 1
synovial fluid 1
cartilage 1
lamina 1
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 628 99.64 Very High Very High Very High
rheumatoid arthritis 220 96.04 Very High Very High Very High
positron emission tomography 3 92.24 High High
imagery 49 84.60 Quite High
Inflammation 75 76.96 Quite High
Morphine 8 56.88 Quite High
anticonvulsant 2 48.76 Quite Low
Substantia nigra 1 46.40 Quite Low
Etanercept 3 37.80 Quite Low
fibrosis 3 33.08 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 74 99.82 Very High Very High Very High
Arthritis 702 99.64 Very High Very High Very High
Disease 100 97.64 Very High Very High Very High
Tremor 1 97.04 Very High Very High Very High
Dystonia 6 96.56 Very High Very High Very High
Rheumatoid Arthritis 220 96.04 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 97 95.36 Very High Very High Very High
Sprains And Strains 103 93.20 High High
Cancer 15 92.92 High High
Necrosis 8 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that cationic antigens such as G6PI bind well to cartilage [62,97].
G6PI Binding (bind) of in cartilage
1) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.87 Pain Relevance 0.29
IgG antibodies are necessary but not sufficient for G6PI-induced arthritis in normal mice
G6PI Neg (not) Binding (sufficient) of associated with arthritis
2) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.47 Pain Relevance 0.52
The autoreactive transgenic T cells recognize G6PI and provide help for the production of arthritogenic IgG antibodies against G6PI.
G6PI Binding (recognize) of in T cells associated with targeted disruption
3) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064898 Disease Relevance 1.14 Pain Relevance 0.34
Within the GPi, regularly, another lamina at about ?
GPi Binding (about) of in lamina
4) Confidence 0.20 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0.29 Pain Relevance 0.07
The most recent development in this diagnostic field is the development of the FLAER reagent.18 FLAER is a fluorochrome-labeled inactive variant of the protein aerolysin which selectively binds directly to the GPI anchor.
GPI Binding (binds) of
5) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 0.49 Pain Relevance 0
B-cell activation in response to G6PI appeared to occur primarily in lymph nodes draining the joints [9], indicating that recognition of G6PI is joint specific.
G6PI Spec (appeared) Binding (recognition) of in joints
6) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 1.14 Pain Relevance 0.26
It would therefore be of interest to identify the G6PI peptide that binds to Aq and to investigate its affinity to the different MHC molecules, in analogy to the CII peptide.
G6PI Binding (binds) of in CII
7) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 1.21 Pain Relevance 0.52
Furthermore, it has been shown that the endocytic route of GPI-APs is cell-type dependent and correlates with their residence time in DRMs.
GPI Binding (route) of
8) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.13 Pain Relevance 0
Through a series of elegant experiments it was demonstrated that this transgenic T-cell receptor recognized G6PI within the context of major histocompatibility complex (MHC) class II molecule Ag7 [3,4].
G6PI Binding (recognized) of in T-cell associated with targeted disruption
9) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 0.85 Pain Relevance 0.16
receptor; FcRn = intracellular Fc receptor; GPI = glucose-6-phosphate isomerase; IC = immune complex; IL = interleukin; IVIG = intravenous therapy with high doses of normal IgG; RA = rheumatoid arthritis; RF = rheumatoid factor; SF = synovial fluid; TNF = tumor necrosis factor.


glucose-6-phosphate Binding (isomerase) of in synovial fluid associated with necrosis, cancer and rheumatoid arthritis
10) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.81 Pain Relevance 0.23
Compared to the body of literature supporting ELF- and VHF-MF drug interactions, investigations examining the effects of SMF on drugs are scarce.
VHF-MF Binding (interactions) of in body
11) Confidence 0.00 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644491 Disease Relevance 0.34 Pain Relevance 0.21

General Comments

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