INT182035

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.95
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
NK cell 2
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 236 99.26 Very High Very High Very High
Inflammation 51 95.56 Very High Very High Very High
rheumatoid arthritis 96 77.12 Quite High
spinal inflammation 4 41.52 Quite Low
cytokine 10 26.40 Quite Low
cva 7 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 262 99.26 Very High Very High Very High
Coronary Artery Disease 53 99.20 Very High Very High Very High
Sprains And Strains 35 96.52 Very High Very High Very High
Targeted Disruption 27 96.48 Very High Very High Very High
INFLAMMATION 52 95.56 Very High Very High Very High
Pressure And Volume Under Development 4 91.20 High High
Disease 57 85.72 High High
Rheumatoid Arthritis 96 77.12 Quite High
Thrombosis 25 72.28 Quite High
Arthus Reaction 8 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arthritis can be induced in recipient mice by transfer of polyclonal IgG1 or combinations of at least two different monoclonal IgG1 antibodies against G6PI [69].
Positive_regulation (transfer) of Gene_expression (transfer) of G6PI associated with arthritis
1) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.02 Pain Relevance 0.37
Mutations of the PIG-A gene disrupt the first step of GPI biosynthesis leading to an absence of the GPI anchor and, in turn, a marked deficiency of all GPI linked proteins.11
Positive_regulation (leading) of Gene_expression (biosynthesis) of GPI
2) Confidence 0.10 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 0.36 Pain Relevance 0
Recent experimental data using the K/B × N arthritis model showed that the pathogenic action of anti-GPI antibodies depends on Fc?
Positive_regulation (depends) of Gene_expression (antibodies) of anti-GPI associated with arthritis
3) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.57 Pain Relevance 0.54
In the protein-induced G6PI model, this has so far not been demonstrated [21], and the antibody titres in the different strains do not exhibit a convincing correlation with arthritis susceptibility.
Positive_regulation (induced) of Gene_expression (model) of G6PI associated with sprains and strains and arthritis
4) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 1.27 Pain Relevance 0.49
Circulating NK cell subsets
Positive_regulation (Circulating) of Gene_expression (subsets) of NK in NK cell
5) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 0.73 Pain Relevance 0

General Comments

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