INT182036

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.74
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sh2b2) cytoplasm (Sh2b2) signal transducer activity (Sh2b2)
Anatomy Link Frequency
SH2 2
T cells 1
Sh2b2 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 102 96.60 Very High Very High Very High
cytokine 80 95.96 Very High Very High Very High
Inflammation 64 95.60 Very High Very High Very High
rheumatoid arthritis 52 95.56 Very High Very High Very High
withdrawal 10 5.00 Very Low Very Low Very Low
Spontaneous pain 10 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
IPN 6 5.00 Very Low Very Low Very Low
allodynia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 120 96.60 Very High Very High Very High
INFLAMMATION 74 95.60 Very High Very High Very High
Rheumatoid Arthritis 52 95.56 Very High Very High Very High
Leukemia 2 84.48 Quite High
Necrosis 2 82.76 Quite High
Cancer 2 82.40 Quite High
Autoimmune Disease 11 66.56 Quite High
Diabetes Mellitus 3 64.24 Quite High
Targeted Disruption 18 50.00 Quite Low
Synovitis 1 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another negative regulator of hematopoietic cell development and function is SHP-1 (SRC homology 2 (SH2)-containing tyrosine phosphatase 1), that is mainly expressed in hematopoietic and lymphoid cells [8].
Gene_expression (containing) of SRC homology 2 in SH2
1) Confidence 0.13 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.36 Pain Relevance 0.13
Another negative regulator of hematopoietic cell development and function is SHP-1 (SRC homology 2 (SH2)-containing tyrosine phosphatase 1), that is mainly expressed in hematopoietic and lymphoid cells [8].
Gene_expression (expressed) of SRC homology 2 in SH2
2) Confidence 0.13 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.37 Pain Relevance 0.13
Second, a spontaneous point mutation in the gene encoding an Src homology 2 (SH2) domain of ZAP-70, a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in mice that resembles human RA in many respects [25].
Gene_expression (domain) of Src homology 2 in T cells associated with rheumatoid arthritis and arthritis
3) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.00 Pain Relevance 0.42

General Comments

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