INT182037

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.69
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
mast cells 2
nucleus 1
whiskers 1
CII 1
interneurons 1
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 38 100.00 Very High Very High Very High
Arthritis 141 99.60 Very High Very High Very High
Hippocampus 15 95.20 Very High Very High Very High
Inflammation 151 88.84 High High
imagery 46 85.96 High High
rheumatoid arthritis 83 82.56 Quite High
unmyelinated 2 79.16 Quite High
positron emission tomography 1 65.56 Quite High
chemokine 6 63.92 Quite High
nav1.8 1 63.88 Quite High
Disease Link Frequency Relevance Heat
Obesity 134 99.74 Very High Very High Very High
Arthritis 165 99.60 Very High Very High Very High
Targeted Disruption 59 95.48 Very High Very High Very High
Apoptosis 63 95.28 Very High Very High Very High
Cognitive Disorder 35 91.88 High High
Disease 102 91.64 High High
Cancer 159 91.12 High High
Sprains And Strains 16 90.04 High High
Hematological Disease 22 89.20 High High
INFLAMMATION 181 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adipocytes express and secrete a variety of adipokines including cytokines, growth factors, adiponectin, resistin, adipsin, leptin, acylation stimulating protein, plasminogen activator inhibitor-1 (PAI-1), lipoprotein lipase, and components of the renin-angiotensin system which may exert local (autocrine/paracrine) and systemic (endocrine) effects [67–69].

5.2.

Localization (secrete) of acylation stimulating protein in Adipocytes associated with obesity and cytokine
1) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.49 Pain Relevance 0.13
Immunofluorescent antibody staining showed large amounts of both complement protein C3 and IgG in the glomerular mesangium and in the capillary loops (data not shown).
Localization (amounts) of C3 in capillary
2) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.57 Pain Relevance 0.06
Genetic deletion of C5, C3 or factor B in DBA/1 mice resulted in each case in mice being highly resistant to CIA induction [23,24] despite the presence of high titers of anti-CII antibodies.
Localization (deletion) of C3 in CII associated with arthritis
3) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.02 Pain Relevance 0.43
RANTES (Ccl5) is chemotactic for mast cells [18] and fragments generated autocatalytically from complement C3 (C3) are capable of stimulating mast cells to release TNF?
Localization (generated) of C3 in mast cells
4) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.55 Pain Relevance 0.11
In contrast to the joints, however, the immune complexes in the kidney were not colocalized with C3 [98].
Neg (not) Localization (colocalized) of C3 in kidney
5) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.98 Pain Relevance 0.25
RANTES (Ccl5) is chemotactic for mast cells [18] and fragments generated autocatalytically from complement C3 (C3) are capable of stimulating mast cells to release TNF?
Localization (generated) of C3 in mast cells
6) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.55 Pain Relevance 0.11
Both IL-6-/- mice and C3-treated mice showed preservation of PV-interneurons in CA3, and C3 rescued interneurons in CA1, as well.
Localization (preservation) of C3 in interneurons
7) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.32 Pain Relevance 0.13
Quantifying the spatial extent of the intrinsic optical signal, the location of the peak response from C1, C2, and C3 whiskers can be easily distinguished, separated by 243??
Localization (response) of C3 in whiskers
8) Confidence 0.17 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0.11
Furthermore, these results can be similarly reproduced using RhoA/ROCK inhibitors (by DN-RhoA transfection, C3 pretreatment or ROCK inhibition with Y-27632), but not inhibiting other geranylated GTPases such as Rac1 or Cdc42.
Localization (pretreatment) of C3
9) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.72 Pain Relevance 0
This activates the phosphatase calcineurin, which dephosphorylates nuclear factor of activated T cells (NFAT) c3 and c4, resulting in translocation to the nucleus.
Localization (translocation) of c3 in nucleus
10) Confidence 0.09 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.22
Patients also underwent immunological tests: (i) determination of C3 and C4 complement components using an immunonephelemetric method (Dade Behring Paris France), (ii) determination of total haemolytic complement using the total haemolytic complement kit (The Binding Site Saint Egreve France), (ii) search for rheumatoid factors, by latex immunoagglutination (Biomérieux Marcy l'Etoile France), (iv) detection of antinuclear antibodies by indirect immunofluorescence (Eurobio Paris France).
Spec (determination) Localization (determination) of C3
11) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2629124 Disease Relevance 0.50 Pain Relevance 0

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