INT182038

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.03
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SH2 4
SH4 1
SH3 1
T cells 1
Sh2 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 101 96.60 Very High Very High Very High
cytokine 40 95.32 Very High Very High Very High
rheumatoid arthritis 51 95.04 Very High Very High Very High
Inflammation 38 94.96 High High
agonist 7 92.24 High High
dexamethasone 16 5.00 Very Low Very Low Very Low
palliative 8 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Spontaneous pain 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 119 96.60 Very High Very High Very High
Rheumatoid Arthritis 51 95.04 Very High Very High Very High
INFLAMMATION 43 94.96 High High
Sprains And Strains 12 91.88 High High
Teratoma 20 88.96 High High
Leukemia 1 83.84 Quite High
Necrosis 2 82.12 Quite High
Cancer 16 81.76 Quite High
Autoimmune Disease 10 66.56 Quite High
Diabetes Mellitus 2 64.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another negative regulator of hematopoietic cell development and function is SHP-1 (SRC homology 2 (SH2)-containing tyrosine phosphatase 1), that is mainly expressed in hematopoietic and lymphoid cells [8].
Gene_expression (expressed) of SH2 in SH2
1) Confidence 0.39 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.37 Pain Relevance 0.13
Second, a spontaneous point mutation in the gene encoding an Src homology 2 (SH2) domain of ZAP-70, a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in mice that resembles human RA in many respects [25].
Gene_expression (domain) of SH2 in T cells associated with rheumatoid arthritis and arthritis
2) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.00 Pain Relevance 0.42
can be recruited to LAT through a direct interaction between LAT Y132 and its N-terminal SH2 domain [37–39].
Gene_expression (domain) of SH2 in SH2
3) Confidence 0.26 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0.05
The antibodies used were: SH2, SH3 and SH4 kindly provided by Dr.
Gene_expression (provided) of SH2 in SH4
4) Confidence 0.05 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
Thus characterization by flow cytometry revealed that AM-hMSCs were positive for SH2 (anti-CD105), SH3 and SH4 (anti-CD73), CD29, CD44, CD166, and negative for the hematopoietic markers CD14, CD34, CD45 (Figure 4).


Neg (negative) Gene_expression (positive) of SH2 in SH2
5) Confidence 0.05 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
The antibodies used were: SH2, SH3 and SH4 kindly provided by Dr.
Gene_expression (provided) of SH2 in SH2
6) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
The antibodies used were: SH2, SH3 and SH4 kindly provided by Dr.
Gene_expression (provided) of SH2 in SH3
7) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
To develop a more definitive and reproducible protocol for the isolation of E-RoSH cell lines, we analyzed the gene expression profiles of RoSH2, E-RoSH2.1, E-RoSH3.2 and E14 ESCs by Illumina microbead array (Data S1) for surface antigens that were differentially expressed in RoSH-like cells and ESCs, and that already have commercially available antibodies.
Spec (analyzed) Gene_expression (expression) of RoSH2
8) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.48 Pain Relevance 0
The gene expression profiles of E-RoSH2.1 and E-RoSH3.2 cells and their parental E14 ESCs have a lower correlation coefficient, r2?
Gene_expression (expression) of RoSH2
9) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.18 Pain Relevance 0

General Comments

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