INT182044

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.38
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc)
Proc (Mus musculus)
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 100 96.40 Very High Very High Very High
Inflammation 8 94.48 High High
Arthritis 200 79.28 Quite High
Demyelination 2 59.48 Quite High
Neuritis 6 58.48 Quite High
Peripheral nervous system 2 52.28 Quite High
fibrosis 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 2 97.66 Very High Very High Very High
Rheumatoid Arthritis 100 96.40 Very High Very High Very High
INFLAMMATION 8 94.48 High High
Arthritis 236 93.96 High High
Myositis 2 93.78 High High
Disease 16 86.16 High High
Autoimmune Disease 18 78.72 Quite High
Targeted Disruption 32 61.72 Quite High
Demyelinating Disease 2 59.48 Quite High
Experimental Autoimmune Neuritis 2 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although some autoantibodies, such as rheumatoid factors that recognize IgG and antibodies against citrullinated antigens, have diagnostic significance [8,29,30], the autoantigen(s) that are recognized in chronic inflammatory arthritides such as RA are unknown [5,16,22,31,32].
factors Binding (recognize) of IgG associated with inflammation, rheumatoid arthritis and arthritis
1) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.41 Pain Relevance 0.58
These include the anti-Jo-1 autoantibodies that bind to and inhibit activity of histidyl-tRNA synthetase, and the autoantibodies that recognize proteasomes that are found in different but overlapping subsets of myositis patients [88-90]; the antimitochondrial antibodies (AMA-2) that recognize the E2 subunit of mitochondrial pyruvate dehydrogenise [91], which are found in patients with primary biliary cirrhosis; the autoantibodies against proteinase 3 (c-ANCAs) in Wegener's granulomatosis [92]; and, of course, the rheumatoid factors that recognize IgG antibodies [8].
factors Binding (recognize) of IgG associated with biliary liver cirrhosis and myositis
2) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.97 Pain Relevance 0.17

General Comments

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