INT182050

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.98
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
retina 3
optic nerve 1
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 7 92.20 High High
Inflammation 64 91.80 High High
cytokine 39 87.04 High High
Multiple sclerosis 11 82.00 Quite High
rheumatoid arthritis 20 81.92 Quite High
Central nervous system 23 80.24 Quite High
chemokine 2 75.68 Quite High
Osteoarthritis 1 73.92 Quite High
nociceptor 1 33.48 Quite Low
ischemia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 6 92.20 High High
Disease 42 90.80 High High
Neurodegenerative Disease 7 85.04 High High
Demyelinating Disease 6 82.00 Quite High
Rheumatoid Arthritis 20 81.92 Quite High
Parkinson's Disease 4 80.40 Quite High
Alzheimer's Dementia 5 78.56 Quite High
Osteoarthritis 1 73.92 Quite High
Glaucoma 74 72.16 Quite High
INFLAMMATION 69 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After DMARD treatment, there was decreased tissue expression of IL-18 that correlated significantly with change in serum IL-18 and C reactive protein.
Negative_regulation (decreased) of Gene_expression (expression) of IL-18
1) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.52 Pain Relevance 0.30
This form was proposed to act as a soluble negative regulator of IL-18 action by stabilizing IL-18 binding to IL-18R?
Negative_regulation (regulator) of Gene_expression (action) of IL-18
2) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.11
We demonstrate in this study of DBA/2J mice that: 1) PEDF protein levels in retina and optic nerve decrease significantly with age; 2) expression of TNF, IL-18, and GFAP in retina and optic nerve increase with age; 3) PEDF transfection reduces age-related RGC loss and vision decline; and 4) PEDF transduction decreases TNF, IL-18, and GFAP expression.
Negative_regulation (decreases) of Gene_expression (expression) of IL-18 in retina
3) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.73 Pain Relevance 0.07
We demonstrate in this study of DBA/2J mice that: 1) PEDF protein levels in retina and optic nerve decrease significantly with age; 2) expression of TNF, IL-18, and GFAP in retina and optic nerve increase with age; 3) PEDF transfection reduces age-related RGC loss and vision decline; and 4) PEDF transduction decreases TNF, IL-18, and GFAP expression.
Negative_regulation (decreases) of in optic nerve Gene_expression (expression) of IL-18 in retina
4) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.73 Pain Relevance 0.07

General Comments

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