INT182059

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.86
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
monocyte 2
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 14 97.44 Very High Very High Very High
Inflammation 65 92.88 High High
cytokine 145 92.36 High High
rheumatoid arthritis 17 90.16 High High
Osteoarthritis 1 85.16 High High
Arthritis 29 77.24 Quite High
Inflammatory mediators 13 50.00 Quite Low
tolerance 2 37.80 Quite Low
Inflammatory response 4 9.16 Low Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 84 92.88 High High
Sepsis 46 92.44 High High
Rheumatoid Arthritis 17 90.16 High High
Infection 40 87.72 High High
Osteoarthritis 1 85.16 High High
Disease 10 78.04 Quite High
Arthritis 39 77.24 Quite High
Alcohol Addiction 13 64.44 Quite High
Increased Venous Pressure Under Development 1 57.68 Quite High
Liver Disease 2 52.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of particular interest, and by contrast to the above mediators, RU induced a slight but significant increase of IL-10 mRNA.
Positive_regulation (induced) of Positive_regulation (increase) of IL-10
1) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.61 Pain Relevance 0.35
The increased levels of IL-10 during an endothelial immune reaction seem to stand in contrast to the functions of IL-10 in that it has primarily immunosuppressive effects by inhibiting the production of pro-inflammatory cytokines, such as IL-1, IL-2, or TNF-?.
Positive_regulation (levels) of Positive_regulation (increased) of IL-10 associated with inflammation and cytokine
2) Confidence 0.13 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2807615 Disease Relevance 0.09 Pain Relevance 0.12
The increased levels of IL-10 during an endothelial immune reaction seem to stand in contrast to the functions of IL-10 in that it has primarily immunosuppressive effects by inhibiting the production of pro-inflammatory cytokines, such as IL-1, IL-2, or TNF-?.
Positive_regulation (increased) of Positive_regulation (levels) of IL-10 associated with inflammation and cytokine
3) Confidence 0.13 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2807615 Disease Relevance 0.09 Pain Relevance 0.12
Considering the ability of IL-10 to inhibit monocyte function, it is likely that elevated IL-10 levels contribute to the disturbed cellular immune response observed after acute alcohol treatment.
Positive_regulation (contribute) of Positive_regulation (elevated) of IL-10 in monocyte associated with alcohol
4) Confidence 0.12 Published 2004 Journal Crit Care Section Body Doc Link PMC1065020 Disease Relevance 1.07 Pain Relevance 0.18

General Comments

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