INT18207

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Context Info
Confidence 0.26
First Reported 1990
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.36
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RPL7AP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
c fibre 7 100.00 Very High Very High Very High
Dorsal horn 7 99.92 Very High Very High Very High
Morphine 7 99.62 Very High Very High Very High
antinociception 4 99.08 Very High Very High Very High
antagonist 11 96.04 Very High Very High Very High
Serotonin 3 95.72 Very High Very High Very High
narcan 6 94.24 High High
Analgesic 3 91.16 High High
tetrodotoxin 2 90.32 High High
Potency 2 90.04 High High
Disease Link Frequency Relevance Heat
Nociception 5 83.68 Quite High
Pressure Volume 2 Under Development 1 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNQX or AP-5 produced a similar reversible inhibition upon pressure ejection in the vagal esophageal afferent projection area.
Gene_expression (produced) of AP-5
1) Confidence 0.26 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 11871782 Disease Relevance 0.06 Pain Relevance 0.41
Microinjection of AP-5 into the NTS produced no significant changes in the baseline MAP and HR.
Gene_expression (Microinjection) of AP-5
2) Confidence 0.03 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12144032 Disease Relevance 0 Pain Relevance 0.56
Fixed ratio dose combinations of morphine and Gal(1-29), or AP-5 and Gal(1-29) produced significantly greater antinociception than predicted from simple additivity.
Gene_expression (produced) of AP-5 associated with antinociception and morphine
3) Confidence 0.03 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610237 Disease Relevance 0.08 Pain Relevance 1.18
AP5 has little effect on C fibre-evoked activity in superficial cells but produced slight inhibitions of the C fibre-evoked responses and clear reductions in the post-discharge of the deep neurones.
Gene_expression (produced) of AP5 associated with c fibre
4) Confidence 0.03 Published 1990 Journal Brain Res. Section Abstract Doc Link 1967963 Disease Relevance 0.22 Pain Relevance 1.29
On the other hand, NMA caused a marked stimulation, whereas AP-5 produced a significant inhibition of GnRH release from the MBHs of orchidectomized guinea pigs; neither of these effects was altered by the presence of naloxone, which, moreover, had only a marginal effect on basal GnRH output in this group of animals.
Gene_expression (produced) of AP-5 associated with narcan
5) Confidence 0.01 Published 1996 Journal Endocrinology Section Abstract Doc Link 8625925 Disease Relevance 0 Pain Relevance 0.43

General Comments

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