INT182073

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.72
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (APEX1) mitochondrion (APEX1) lyase activity (APEX1)
ribosome (APEX1) endoplasmic reticulum (APEX1) intracellular (APEX1)
Anatomy Link Frequency
lung 1
APEX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 4 100.00 Very High Very High Very High
anesthesia 2 99.92 Very High Very High Very High
Multiple sclerosis 2 99.42 Very High Very High Very High
tolerance 10 90.28 High High
Inflammation 3 52.48 Quite High
rheumatoid arthritis 2 50.00 Quite Low
adenocard 1 13.76 Low Low
imagery 5 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 99.64 Very High Very High Very High
Demyelinating Disease 2 99.42 Very High Very High Very High
Lung Cancer 2 99.10 Very High Very High Very High
Cancer 78 98.80 Very High Very High Very High
Autoimmune Disease 10 93.44 High High
Disease 78 82.40 Quite High
Neurological Disease 4 74.80 Quite High
Syndrome 11 59.28 Quite High
Myasthenia Gravis 54 57.56 Quite High
Bullous Skin Disease 2 55.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MUTYH has also binding sites for a DNA binding domain, an adenine binding motif and several interaction domains for apurinic endonuclease 1 (APE1) enzyme, proliferating-cell nuclear antigen (PCNA), replication protein A (RPA) and MSH6, located in different regions of the gene (Fig. 8).


APE1 Binding (binding) of
1) Confidence 0.12 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0 Pain Relevance 0
ApEn then measures the difference between the logarithmic frequencies of similar runs of length m and runs with the length m+1.
ApEn Binding (runs) of
2) Confidence 0.11 Published 2004 Journal Crit Care Section Body Doc Link PMC1065053 Disease Relevance 0 Pain Relevance 0.05
For example, antibodies directed to voltage-gated calcium channels expressed on the surface of small cell lung cancer cells can cause neurological dysfunction by binding to similar calcium channels on the motor nerve endings (see Ref. 4).
Ref Binding (binding) of in lung associated with anesthesia, lung cancer and calcium channel
3) Confidence 0.05 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 1.37 Pain Relevance 0.23
For instance, one might choose to screen a large number of multiple sclerosis patient sera for antibodies binding the cell membranes of oligodendroglial cells (as for instance in Ref. 14) or diabetic patient sera for antibodies binding the cell membranes of pancreatic beta islet cells.
Ref Spec (might) Binding (binding) of associated with multiple sclerosis and diabetes mellitus
4) Confidence 0.03 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.35 Pain Relevance 0.05
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro.
apurinic-endonuclease Binding (binding) of
5) Confidence 0.01 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0

General Comments

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