INT182077

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.65
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RFC1) nucleus (RFC1) intracellular (RFC1)
RFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 174 99.96 Very High Very High Very High
adenocard 32 98.92 Very High Very High Very High
antagonist 38 97.60 Very High Very High Very High
Inflammation 8 75.68 Quite High
Potency 28 65.60 Quite High
ischemia 2 21.96 Low Low
tolerance 6 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 13 99.58 Very High Very High Very High
Disorder Of Lipid Metabolism 20 91.00 High High
Coronary Stenosis 1 88.92 High High
INFLAMMATION 8 75.68 Quite High
Coronary Heart Disease 12 70.72 Quite High
Metabolic Syndrome 3 70.08 Quite High
Insulin Resistance 1 65.20 Quite High
Hyperlipidemia 1 64.20 Quite High
Infection 3 31.12 Quite Low
Obesity 3 26.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PD81,723 alone behaves as an allosteric agonist, promoting the A1 AR to its active conformation (R*) and, thus, potentiates the A1 AR constitutive receptor activity.
Positive_regulation (promoting) of A1 associated with agonist
1) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.49
Adenosine receptors (ARs) are G protein-coupled receptors, consisting of A1, A2A, A2B and A3 subtypes, activated by the endogenous agonist adenosine and blocked by natural antagonists, such as caffeine and theophylline.
Positive_regulation (activated) of A1 associated with adenocard, antagonist and agonist
2) Confidence 0.03 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.29
A single scaling exponent represents the limit as N and n approach infinity; however, applicable to real life data sets, the linear relationship between log F(n) and log n has been noted to be distinct for small n (n < 11) and large n (11 < n > 10,000), yielding two lines with two slopes, labelled the scaling exponents a1 and a2, respectively.
Positive_regulation (exponents) of a1
3) Confidence 0.03 Published 2004 Journal Crit Care Section Body Doc Link PMC1065053 Disease Relevance 0 Pain Relevance 0
In keeping with these early results, in the INTERHEART case-control study on risk factors associated with myocardial infarction in 52 countries, an increase in apo B/apo A1 ratio was shown to be the strongest risk factor for myocardial infarction [5].
Positive_regulation (increase) of A1 associated with myocardial infarction
4) Confidence 0.02 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2039733 Disease Relevance 1.65 Pain Relevance 0.04

General Comments

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