INT182077

Context Info Confidence 0.07 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.65 Pain Relevance 0.81

nucleoplasm (RFC1) nucleus (RFC1) intracellular (RFC1)

RFC1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 174 99.96 adenocard 32 98.92 antagonist 38 97.60 Inflammation 8 75.68 Potency 28 65.60 ischemia 2 21.96 tolerance 6 5.00 Bioavailability 5 5.00 cytokine 4 5.00 Neuropathic pain 2 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 13 99.58 Disorder Of Lipid Metabolism 20 91.00 Coronary Stenosis 1 88.92 INFLAMMATION 8 75.68 Coronary Heart Disease 12 70.72 Metabolic Syndrome 3 70.08 Insulin Resistance 1 65.20 Hyperlipidemia 1 64.20 Infection 3 31.12 Obesity 3 26.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PD81,723 alone behaves as an allosteric agonist, promoting the A1 AR to its active conformation (R*) and, thus, potentiates the A1 AR constitutive receptor activity.

Positive_regulation (promoting) of A1 associated with agonist

1) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.49

Adenosine receptors (ARs) are G protein-coupled receptors, consisting of A1, A2A, A2B and A3 subtypes, activated by the endogenous agonist adenosine and blocked by natural antagonists, such as caffeine and theophylline.

Positive_regulation (activated) of A1 associated with adenocard, antagonist and agonist

2) Confidence 0.03 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.29

A single scaling exponent represents the limit as N and n approach infinity; however, applicable to real life data sets, the linear relationship between log F(n) and log n has been noted to be distinct for small n (n < 11) and large n (11 < n > 10,000), yielding two lines with two slopes, labelled the scaling exponents a1 and a2, respectively.

Positive_regulation (exponents) of a1

3) Confidence 0.03 Published 2004 Journal Crit Care Section Body Doc Link PMC1065053 Disease Relevance 0 Pain Relevance 0

In keeping with these early results, in the INTERHEART case-control study on risk factors associated with myocardial infarction in 52 countries, an increase in apo B/apo A1 ratio was shown to be the strongest risk factor for myocardial infarction [5].

Positive_regulation (increase) of A1 associated with myocardial infarction

4) Confidence 0.02 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2039733 Disease Relevance 1.65 Pain Relevance 0.04

General Comments

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