INT182078

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.77
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (APEX1) mitochondrion (APEX1) lyase activity (APEX1)
ribosome (APEX1) endoplasmic reticulum (APEX1) intracellular (APEX1)
Anatomy Link Frequency
brains 3
pituitary 2
APEX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 4 93.72 High High
Central nervous system 4 54.84 Quite High
tolerance 10 10.88 Low Low
Angina 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 534 99.84 Very High Very High Very High
Acromegaly 8 99.36 Very High Very High Very High
Neuritis 4 93.72 High High
Cv Unclassified Under Development 2 82.88 Quite High
Sudden Infant Death Syndrome 2 79.96 Quite High
Diabetes Mellitus 4 74.24 Quite High
Arrhythmias 2 Under Development 4 73.44 Quite High
Cognitive Disorder 132 72.88 Quite High
Toxicity 8 70.96 Quite High
Syndrome 8 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding that AP-site incision activity and APE1 protein levels were similar in brains of AD patients and controls differs from previous reports of increased APE1 expression in AD (13,14).
Gene_expression (expression) of APE1 in brains associated with disease
1) Confidence 0.59 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.85 Pain Relevance 0
The finding that AP-site incision activity and APE1 protein levels were similar in brains of AD patients and controls differs from previous reports of increased APE1 expression in AD (13,14).
Gene_expression (levels) of APE1 in brains associated with disease
2) Confidence 0.51 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.81 Pain Relevance 0
However, only expression levels and not APE1 activity was reported in the previous studies.
Gene_expression (expression) of APE1
3) Confidence 0.51 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.95 Pain Relevance 0
was reported in midtemporal cortex samples from AD patients (12); in contrast, expression of APE1 was higher in affected brain tissue (13) and in extracts of brain cells from AD patients (14).
Gene_expression (expression) of APE1 in brain associated with disease
4) Confidence 0.46 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.95 Pain Relevance 0.12
By applying ApEn to measurements of growth hormone (GH) every 5 min for 24 hours in healthy control individuals and patients with acromegaly, reduced orderliness (i.e. increased ApEn) was observed in acromegaly [125]; and normalization of GH ApEn values was demonstrated after pituitary surgery for acromegaly [126].
Gene_expression (values) of ApEn in pituitary associated with acromegaly
5) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC1065053 Disease Relevance 0.63 Pain Relevance 0
By applying ApEn to measurements of growth hormone (GH) every 5 min for 24 hours in healthy control individuals and patients with acromegaly, reduced orderliness (i.e. increased ApEn) was observed in acromegaly [125]; and normalization of GH ApEn values was demonstrated after pituitary surgery for acromegaly [126].
Gene_expression (applying) of ApEn in pituitary associated with acromegaly
6) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC1065053 Disease Relevance 0.57 Pain Relevance 0

General Comments

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