INT182080

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.30
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (APEX1) mitochondrion (APEX1) lyase activity (APEX1)
ribosome (APEX1) endoplasmic reticulum (APEX1) intracellular (APEX1)
Anatomy Link Frequency
pituitary 1
APEX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 93.96 High High
Neuritis 2 36.72 Quite Low
tolerance 5 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acromegaly 4 99.76 Very High Very High Very High
Disease 267 99.04 Very High Very High Very High
Cv Unclassified Under Development 1 74.12 Quite High
Aging 12 73.92 Quite High
Diabetes Mellitus 2 73.68 Quite High
Sudden Infant Death Syndrome 1 71.20 Quite High
Arrhythmias 2 Under Development 2 64.68 Quite High
Cognitive Disorder 66 56.40 Quite High
Neurodegenerative Disease 4 55.44 Quite High
Hypercalcemia 1 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first step of BER is the removal of the damaged base by a substrate-specific DNA glycosylase, generating an abasic (AP) site, which is cleaved by an AP lyase or AP endonuclease (i.e.
Localization (cleaved) of AP lyase
1) Confidence 0.57 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.62 Pain Relevance 0.05
As for the IPL, AP incision activity and APE1 protein level was similar in CE from AD patients and controls (Figure 3C).
Localization (level) of APE1 associated with disease
2) Confidence 0.57 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 1.04 Pain Relevance 0
By applying ApEn to measurements of growth hormone (GH) every 5 min for 24 hours in healthy control individuals and patients with acromegaly, reduced orderliness (i.e. increased ApEn) was observed in acromegaly [125]; and normalization of GH ApEn values was demonstrated after pituitary surgery for acromegaly [126].
Localization (normalization) of ApEn in pituitary associated with acromegaly
3) Confidence 0.23 Published 2004 Journal Crit Care Section Body Doc Link PMC1065053 Disease Relevance 0.64 Pain Relevance 0

General Comments

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