INT182096

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.26
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
monocytes 2
Il6 (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 65 95.60 Very High Very High Very High
cytokine 67 86.80 High High
cINOD 14 82.16 Quite High
Potency 1 77.80 Quite High
Inflammatory mediators 8 77.64 Quite High
COX-2 inhibitor 6 67.60 Quite High
Inflammatory stimuli 1 59.68 Quite High
glial activation 8 50.00 Quite Low
Pain 2 28.64 Quite Low
antagonist 2 5.44 Low Low
Disease Link Frequency Relevance Heat
Disease 49 100.00 Very High Very High Very High
Cancer 8 99.56 Very High Very High Very High
Necrosis 7 99.32 Very High Very High Very High
INFLAMMATION 85 95.60 Very High Very High Very High
Amyloid Plaque 32 93.72 High High
Death 7 84.16 Quite High
Cognitive Disorder 6 74.80 Quite High
Alzheimer's Dementia 32 70.64 Quite High
Sepsis 51 70.40 Quite High
Hemorrhage 3 69.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to histopathological and biochemical data, several proinflammatory genes have been linked to an increased risk for AD, including interleukin1 (Il-1) [12], interleukin 6 (Il-6) [13] and tumor necrosis factor alpha (TNF?)
Positive_regulation (increased) of interleukin 6 Binding (interleukin1) of Il-1 associated with necrosis, cancer and disease
1) Confidence 0.09 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 1.80 Pain Relevance 0.45
In addition to histopathological and biochemical data, several proinflammatory genes have been linked to an increased risk for AD, including interleukin1 (Il-1) [12], interleukin 6 (Il-6) [13] and tumor necrosis factor alpha (TNF?)
Positive_regulation (increased) of Il-6 Binding (interleukin1) of Il-1 associated with necrosis, cancer and disease
2) Confidence 0.09 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 1.80 Pain Relevance 0.45
It also exhibited marked inhibitory properties on endotoxin-induced IL-6 formation in THP1 monocytes, with less activity on TNF and IL-1?.
Positive_regulation (induced) of IL-6 Binding (formation) of IL-1 in monocytes
3) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 0.66 Pain Relevance 0.41

General Comments

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