INT182097

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.67
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
monocytes 1
T cells 1
Il6 (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 100 97.52 Very High Very High Very High
Inflammation 80 94.28 High High
cINOD 14 82.16 Quite High
Potency 1 77.48 Quite High
Inflammatory mediators 8 76.32 Quite High
Arthritis 86 68.08 Quite High
COX-2 inhibitor 6 67.28 Quite High
Inflammatory stimuli 1 59.36 Quite High
glial activation 8 50.00 Quite Low
Inflammatory response 4 41.84 Quite Low
Disease Link Frequency Relevance Heat
Disease 79 99.76 Very High Very High Very High
Cancer 10 99.56 Very High Very High Very High
Necrosis 9 99.32 Very High Very High Very High
INFLAMMATION 97 94.28 High High
Amyloid Plaque 32 92.40 High High
Multiple Sclerosis 7 92.12 High High
Death 7 82.84 Quite High
Arthropathy 4 78.04 Quite High
Cognitive Disorder 6 74.80 Quite High
Sepsis 51 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to histopathological and biochemical data, several proinflammatory genes have been linked to an increased risk for AD, including interleukin1 (Il-1) [12], interleukin 6 (Il-6) [13] and tumor necrosis factor alpha (TNF?)
interleukin 6 Binding (interleukin1) of Il-1 associated with necrosis, cancer and disease
1) Confidence 0.07 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 1.78 Pain Relevance 0.44
In addition to histopathological and biochemical data, several proinflammatory genes have been linked to an increased risk for AD, including interleukin1 (Il-1) [12], interleukin 6 (Il-6) [13] and tumor necrosis factor alpha (TNF?)
Il-6 Binding (interleukin1) of Il-1 associated with necrosis, cancer and disease
2) Confidence 0.07 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 1.78 Pain Relevance 0.45
Moreover, IL-1 signaling in T cells was required in dendritic cell-mediated Th17 cell differentiation from naïve or regulatory precursors and IL-1 synergized with IL-6 and IL-23 to regulate Th17 cell differentiation and maintain cytokine expression in effector Th17 cells [11].
IL-6 Binding (synergized) of IL-1 in T cells associated with cytokine
3) Confidence 0.01 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.50 Pain Relevance 0.24
It also exhibited marked inhibitory properties on endotoxin-induced IL-6 formation in THP1 monocytes, with less activity on TNF and IL-1?.
IL-6 Binding (formation) of IL-1 in monocytes
4) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 0.60 Pain Relevance 0.41

General Comments

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