INT182125

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.78
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD14, TLR4) signal transduction (TLR4) extracellular space (CD14)
extracellular region (CD14) intracellular (TLR4) cytoplasm (TLR4)
Anatomy Link Frequency
MD2 2
brains 1
endometrium 1
Kupffer cells 1
CD14 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 112 99.48 Very High Very High Very High
agonist 54 99.26 Very High Very High Very High
Bile 8 97.76 Very High Very High Very High
Inflammation 162 97.24 Very High Very High Very High
medulla 3 96.36 Very High Very High Very High
fibrosis 37 87.76 High High
ischemia 5 84.80 Quite High
metalloproteinase 10 71.12 Quite High
Inflammatory mediators 8 61.40 Quite High
Inflammatory response 44 53.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 212 97.24 Very High Very High Very High
Stress 120 97.12 Very High Very High Very High
Infection 67 95.28 Very High Very High Very High
Death 65 94.80 High High
Bacterial Meningitis 2 94.40 High High
Cirrhosis 106 88.24 High High
Disease 47 86.76 High High
Cv Unclassified Under Development 6 84.80 Quite High
Adhesions 18 84.24 Quite High
Alzheimer's Dementia 2 84.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.
CD14 Binding (interacting) of TLR4 in endometrium
1) Confidence 0.25 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.31 Pain Relevance 0.08
The binding and activation of LPS to TLR4 needs three additional components: MD2, a membrane protein whose association with TLR4 is required for the binding of LPS [5]; LPS-binding protein (LBP), which extracts LPS monomers from the aggregated form [6,7]; and CD14, which transfers LPS to the TLR4/MD2 transmembrane co-receptor, which then triggers the downstream molecular events [2].
CD14 Binding (association) of TLR4 in MD2
2) Confidence 0.24 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.19 Pain Relevance 0.14
CD14 receptors then interact with the Toll-like receptor 4, initiating cytokine production [22,23].
CD14 Binding (interact) of Toll-like receptor 4 associated with cytokine
3) Confidence 0.20 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.43 Pain Relevance 0.08
The uptake of LPS by hepatocytes in vivo is through a CD14-TLR4-MD2-dependent mechanism, and is mediated by ?
CD14 Binding (mechanism) of TLR4 in MD2 associated with agonist
4) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.02 Pain Relevance 0.39
TLR4, which interacts with LPS-bound CD14, is constitutively expressed in circumventricular organs but also in the hypothalamus and medulla; in contrast to CD14, however, there is a downregulation of TLR4 mRNA in the brains of rats challenged by LPS [59].
CD14 Binding (interacts) of TLR4 in brains associated with medulla
5) Confidence 0.15 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.37 Pain Relevance 0.08
This is likely to be significantly related to levels of TNF in the chronic inflammatory environment as well as to increased translocation of gut-derived endotoxins to the portal circulation, as clearly described in the case of chronic ethanol ingestion and the subsequent interaction of endotoxins with CD14 and TLR-4 in Kupffer cells [243].


CD14 Binding (interaction) of TLR-4 in Kupffer cells associated with inflammation
6) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.11 Pain Relevance 0.13
derivatives bind TLR4-CD14 complexes on
CD14 Binding (complexes) of TLR4
7) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.35 Pain Relevance 0.12

General Comments

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