INT182137

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2011
Negated 0
Speculated 7
Reported most in Body
Documents 137
Total Number 147
Disease Relevance 48.48
Pain Relevance 9.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR9) signal transduction (TLR9) extracellular region (TLR9)
endoplasmic reticulum (TLR9) plasma membrane (TLR9) intracellular (TLR9)
Anatomy Link Frequency
monocytes 20
alveolar macrophages 12
leukocyte 9
macrophages 7
lymphocytes 7
TLR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1775 99.64 Very High Very High Very High
Multiple sclerosis 84 99.28 Very High Very High Very High
cytokine 1396 98.92 Very High Very High Very High
agonist 136 96.88 Very High Very High Very High
Inflammatory response 117 96.04 Very High Very High Very High
anesthesia 205 89.68 High High
Bile 17 88.92 High High
ischemia 7 82.56 Quite High
Inflammatory mediators 10 80.88 Quite High
Central nervous system 54 80.84 Quite High
Disease Link Frequency Relevance Heat
Death 26 99.82 Very High Very High Very High
Hypersensitivity 1923 99.76 Very High Very High Very High
Mycobacterial Infection 1345 99.72 Very High Very High Very High
INFLAMMATION 1892 99.64 Very High Very High Very High
Rhinitis 1672 99.60 Very High Very High Very High
Critical Illness 75 99.56 Very High Very High Very High
Cold Sores 367 99.32 Very High Very High Very High
Primary Sclerosing Cholangitis 1 99.30 Very High Very High Very High
Demyelinating Disease 91 99.28 Very High Very High Very High
Recurrence 48 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA expression of TLR9 has been demonstrated in sinonasal tissue and expression of TLR9 mRNA and protein has been reported in human cell lines and primary cells of lower airway epithelium [14,15].
Gene_expression (expression) of TLR9 in epithelium
1) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.39 Pain Relevance 0.09
Whereas expression of TLR9 has been demonstrated in human peripheral blood-derived cultured mast cells [32,33], mast cells in the conjunctiva did not stain for TLR9 protein [19].
Gene_expression (expression) of TLR9 in blood
2) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.16 Pain Relevance 0.05
Expression of TLR9 was found in different inflammatory cells (i.e. leukocytes) in the epithelial and subepithelial region.
Gene_expression (Expression) of TLR9 in leukocytes associated with inflammation
3) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.22 Pain Relevance 0.08
Human tonsil B cells express high amounts of TLR9 mRNA and protein as determined by Western blot [35], which together with a low surface staining indicate a predominantly intracellular expression of TLR9 in lymphocytes.
Gene_expression (expression) of TLR9 in lymphocytes
4) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0 Pain Relevance 0
The increased expression of TLR9 in nasal lavage fluid indicates either that neutrophils expressing high levels of TLR9 are preferentially recruited to the nose (via the bloodstream from the bone marrow reservoir), or that neutrophils are primed with an increased expression of TLR9 as they migrate towards the nasal lumen.
Gene_expression (expression) of TLR9 in reservoir
5) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.24 Pain Relevance 0.05
Flow cytometry analysis of TLR9 leukocyte expression was performed on samples obtained during symptomatic allergic rhinitis.
Gene_expression (expression) of TLR9 in leukocyte associated with rhinitis
6) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.68 Pain Relevance 0
Intracellular expression of TLR9 was evident in neutrophils in nasal lavage fluid (Figure 3).


Gene_expression (expression) of TLR9 in nasal
7) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.11 Pain Relevance 0
This finding is in agreement with a previous study where a minor proportion of freshly isolated CD14+ monocytes and B-cells were shown to express TLR9 on their cell surfaces [16].
Gene_expression (express) of TLR9 in B-cells
8) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.06 Pain Relevance 0.03
Human tonsil B cells express high amounts of TLR9 mRNA and protein as determined by Western blot [35], which together with a low surface staining indicate a predominantly intracellular expression of TLR9 in lymphocytes.
Gene_expression (express) of TLR9 in lymphocytes
9) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.06 Pain Relevance 0.03
Expression of functional TLR9 was detected in a study using a human bronchial epithelial cell line [30].
Gene_expression (Expression) of TLR9 in epithelial cell
10) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.28 Pain Relevance 0.07
The high expression of TLR9 in immature (CD16-negative) granulocytes in bone marrow supports this view.
Gene_expression (expression) of TLR9 in bone marrow
11) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.15 Pain Relevance 0.03
First, the intracellular expression of TLR9, as measured by MFIR, was compared between the different compartments irrespective of the atopic status of the individuals from which the cells were obtained.
Gene_expression (expression) of TLR9
12) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0 Pain Relevance 0
The increased expression of TLR9 in nasal lavage fluid indicates either that neutrophils expressing high levels of TLR9 are preferentially recruited to the nose (via the bloodstream from the bone marrow reservoir), or that neutrophils are primed with an increased expression of TLR9 as they migrate towards the nasal lumen.
Gene_expression (expressing) of TLR9 in reservoir
13) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.24 Pain Relevance 0.05
Intracellular expression of TLR9 was found in bone marrow leukocytes.
Gene_expression (expression) of TLR9 in bone marrow
14) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0 Pain Relevance 0
In addition, TLR9 was expressed in basophils, monocytes and lymphocytes.
Gene_expression (expressed) of TLR9 in monocytes
15) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.07 Pain Relevance 0.03
Thus, it is possible that the expression of TLR9 has a role in the development and differentiation of granulocytes.
Gene_expression (expression) of TLR9 in granulocytes
16) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.13 Pain Relevance 0.03
The expression of TLR9 was assessed in nasal biopsies using immunohistochemistry before and after allergen challenge.
Gene_expression (expression) of TLR9 in nasal
17) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.92 Pain Relevance 0.09
Immunohistochemical analysis suggested an expression of TLR9 in intra- and subepithelial lymphocytes and granulocytes.
Gene_expression (expression) of TLR9 in lymphocytes
18) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.08 Pain Relevance 0.04
In the present study, expression of TLR9 was found in the endothelial lining of small blood vessels.
Gene_expression (expression) of TLR9 in blood vessels
19) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.28 Pain Relevance 0.07
The intracellular expression of TLR9 in neutrophils was found to be higher in bone marrow and nasal lavage fluid, 3.26 ± 0.33 and 3.98 ± 0.38, respectively, compared to in peripheral blood, 2.24 ± 0.10 (p < 0.001 and p < 0.01, respectively; Figure 4A).
Gene_expression (expression) of TLR9 in neutrophils
20) Confidence 0.78 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0 Pain Relevance 0

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