INT182168

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.71
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAX) plasma membrane (ITGAX)
Anatomy Link Frequency
DCs 1
T cells 1
ITGAX (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 261 100.00 Very High Very High Very High
Inflammation 36 99.44 Very High Very High Very High
imagery 3 57.12 Quite High
Intracerebroventricular 1 18.80 Low Low
cytokine 42 5.00 Very Low Very Low Very Low
Central nervous system 38 5.00 Very Low Very Low Very Low
chemokine 14 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 261 100.00 Very High Very High Very High
INFLAMMATION 36 99.44 Very High Very High Very High
Arthritis 3 98.20 Very High Very High Very High
Overdose 1 78.44 Quite High
Death 3 66.96 Quite High
Cancer 12 60.96 Quite High
Necrosis 9 60.48 Quite High
Multiple Sclerosis 79 57.08 Quite High
Immunization 5 16.60 Low Low
Paralysis 3 12.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sections were then incubated overnight at 4°C with mouse monoclonal antibodies directed against CD11b/CD11c (OX42), MHC class II molecules (OX6) or myelin basic protein.
Localization (directed) of CD11c
1) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2552991 Disease Relevance 0.14 Pain Relevance 0.03
Differentiated nuclear RelB+ DCs are found within the CD11c+ DC population in RA and other inflammatory arthritides but not in normal synovial tissue [21].


Neg (not) Localization (found) of CD11c associated with inflammation, rheumatoid arthritis and arthritis
2) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.31 Pain Relevance 0.61
CD11c+ myeloid DCs and CD123+ pDCs were compared in normal and RA PB, synovial fluid (SF), and synovial tissue by flow cytometry, immunohistochemistry, and electron microscopy and were sorted for functional studies.
Localization (sorted) of CD11c in DCs associated with rheumatoid arthritis
3) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.93 Pain Relevance 0.40
To analyse the functional capability of RA SF DCs, CD11c+ and CD123+ DCs were sorted from either normal PB or RA SF and incubated with freshly isolated normal allogeneic PB T cells.
Spec (analyse) Localization (capability) of CD11c in T cells associated with rheumatoid arthritis
4) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.34 Pain Relevance 0.14

General Comments

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