INT182170

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.78
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELB) cytoskeleton (RELB) nucleus (RELB)
DNA binding (RELB) microtubule organizing center (RELB) cytoplasm (RELB)
Anatomy Link Frequency
nucleus 3
synovium 2
tonsil 2
CD86 1
B-cell 1
RELB (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 58 99.84 Very High Very High Very High
Inflammation 168 99.72 Very High Very High Very High
rheumatoid arthritis 1124 98.88 Very High Very High Very High
cytokine 191 86.96 High High
Multiple sclerosis 12 63.92 Quite High
psoriasis 12 61.64 Quite High
Arthritis 21 53.00 Quite High
Pain 24 27.32 Quite Low
Nicotine 3 9.60 Low Low
alcohol 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 177 99.72 Very High Very High Very High
Rheumatoid Arthritis 1125 98.88 Very High Very High Very High
Arthritis 24 97.52 Very High Very High Very High
Disease 79 85.04 High High
Necrosis 38 83.40 Quite High
Cancer 51 83.04 Quite High
Systemic Lupus Erythematosus 36 74.56 Quite High
Rheumatic Diseases 1 74.44 Quite High
Virus Diseases 12 68.12 Quite High
Reprotox - General 1 12 65.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data suggest either that activation of pDCs is not associated with nuclear translocation and transcriptional activity of RelB or that conditions in tonsil and synovium do not induce sufficient RelB translocation for detection by immunohistochemistry [26,57].
Localization (translocation) of RelB in synovium
1) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.46 Pain Relevance 0.21
Differentiated nuclear RelB+ DCs are found within the CD11c+ DC population in RA and other inflammatory arthritides but not in normal synovial tissue [21].


Neg (not) Localization (found) of RelB associated with inflammation, rheumatoid arthritis and arthritis
2) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.31 Pain Relevance 0.61
These nuclear RelB+ DCs are absent in normal synovial tissue and are rare in RA SF [21,23].
Neg (absent) Localization (nuclear) of RelB associated with rheumatoid arthritis
3) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.50 Pain Relevance 0.25
In contrast, CD11c+ myeloid precursors populate normal resting tissues, as shown here, but additional CD11c+ myeloid cellular recruitment takes place at inflammatory sites, where RelB nuclear translocation takes place [21,56].
Localization (translocation) of RelB associated with inflammation
4) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.51 Pain Relevance 0.20
Nuclear RelB-CD123+ DCs were located in perivascular regions of RA, in a similar frequency to nuclear RelB+CD123- DCs, but not normal synovial tissue sublining.
Localization (located) of RelB in DCs associated with rheumatoid arthritis
5) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.95 Pain Relevance 0.41
No CD123+ cells had translocated RelB to the nucleus, although some expressed cytoplasmic RelB (Fig. 1h,1i).
Localization (translocated) of RelB in nucleus
6) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.42 Pain Relevance 0.21
The data suggest either that activation of pDCs is not associated with nuclear translocation and transcriptional activity of RelB or that conditions in tonsil and synovium do not induce sufficient RelB translocation for detection by immunohistochemistry [26,57].
Localization (translocation) of RelB in synovium
7) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.46 Pain Relevance 0.21
Translocation of RelB to the nucleus is associated with maturation and APC function of myeloid DCs [26].
Localization (Translocation) of RelB in nucleus
8) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.48 Pain Relevance 0.24
However, when freshly isolated, only a small proportion of SF CD33brightCD14- DCs have translocated RelB to the nucleus.
Localization (translocated) of RelB in nucleus
9) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.25 Pain Relevance 0.58
Translocation of RelB to the nucleus of myeloid DCs is associated with APC function, particularly through increased expression of MHC molecules CD86 and CD40 [26].
Localization (Translocation) of RelB in CD86
10) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.10 Pain Relevance 0.47
The data suggest either that activation of pDCs is not associated with nuclear translocation and transcriptional activity of RelB or that conditions in tonsil and synovium do not induce sufficient RelB translocation for detection by immunohistochemistry [26,57].
Localization (translocation) of RelB in tonsil
11) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.46 Pain Relevance 0.21
The data suggest either that activation of pDCs is not associated with nuclear translocation and transcriptional activity of RelB or that conditions in tonsil and synovium do not induce sufficient RelB translocation for detection by immunohistochemistry [26,57].
Localization (translocation) of RelB in tonsil
12) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.46 Pain Relevance 0.21
In contrast, myeloid DC precursors populate normal resting synovial tissues – but additional CD11c+ myeloid cellular recruitment takes place at the RA synovial inflammatory site in response to inflammatory chemokines, where RelB nuclear translocation associated with DC maturation may take place [16].
Localization (translocation) of RelB associated with chemokine, inflammation and rheumatoid arthritis
13) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 1.06 Pain Relevance 0.55
receptor and the B-cell–activating factor of the TNF family (BAFF) leads to the release of p52:RelB dimers via the alternative IKK1/NIK-dependent pathway (reviewed in [12]).
Localization (release) of RelB in B-cell
14) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

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