INT182175

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.27
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IL3RA)
Anatomy Link Frequency
monocytes 2
basophils 2
macrophages 1
blood vessels 1
IL3RA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 698 99.84 Very High Very High Very High
Inflammation 134 77.84 Quite High
psoriasis 10 12.88 Low Low
Arthritis 10 12.08 Low Low
cytokine 120 5.00 Very Low Very Low Very Low
Chronic pancreatitis 50 5.00 Very Low Very Low Very Low
chemokine 32 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
spinal inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 698 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 24 86.32 High High
Arthritis 10 78.32 Quite High
INFLAMMATION 136 77.84 Quite High
Cancer 196 69.20 Quite High
Adenocarcinoma 192 60.16 Quite High
Disease 72 50.00 Quite Low
Leukemia 2 42.56 Quite Low
Carcinoma 58 39.28 Quite Low
Infection 2 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A population of CD123+ cells with dendritic appearance was also stained adjacent to CD123+ blood vessels in RA (Fig. 1c,1d,).
Gene_expression (blood vessels) of CD123 in blood vessels associated with rheumatoid arthritis
1) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.77 Pain Relevance 0.38
Since basophils and monocytes can also express CD123, potential CD123+ non-DCs were excluded by gating CD14-HLA-DR+ cells [10].
Gene_expression (express) of CD123 in monocytes
2) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.07 Pain Relevance 0.47
Since basophils and monocytes can also express CD123, potential CD123+ non-DCs were excluded by gating CD14-HLA-DR+ cells [10].
Gene_expression (express) of CD123 in monocytes
3) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.01 Pain Relevance 0.44
While some macrophages can express CD123, there was no colocalization in synovial tissue of CD123 and CD68 (data not shown).
Gene_expression (express) of CD123 in macrophages
4) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.39 Pain Relevance 0.20
To examine plasmacytoid and myeloid DCs in parallel, we compared RA SF with RA and healthy, control PB for the proportion of CD123+ and CD11c+ HLA-DR+CD14- DCs.
Gene_expression (proportion) of CD123 associated with rheumatoid arthritis
5) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.22 Pain Relevance 0.57
The percentages of CD123+CD11c- pDCs in RA PB and normal PB were low and did not differ from each other.
Gene_expression (percentages) of CD123+ associated with rheumatoid arthritis
6) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.11 Pain Relevance 0.48
MDCs express high levels of CD11c, BDCA1, and BDCA3 and myeloid related surface molecules, whereas PDCs lack the myeloid markers including CD11c, but they express the IL-3 receptor (CD123) [13].
Gene_expression (express) of IL-3 receptor
7) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 0.31 Pain Relevance 0
MDCs express high levels of CD11c, BDCA1, and BDCA3 and myeloid related surface molecules, whereas PDCs lack the myeloid markers including CD11c, but they express the IL-3 receptor (CD123) [13].
Gene_expression (express) of CD123
8) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 0.31 Pain Relevance 0
Since basophils and monocytes can also express CD123, potential CD123+ non-DCs were excluded by gating CD14-HLA-DR+ cells [10].
Gene_expression (express) of CD123 in basophils
9) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.07 Pain Relevance 0.47
Since basophils and monocytes can also express CD123, potential CD123+ non-DCs were excluded by gating CD14-HLA-DR+ cells [10].
Gene_expression (express) of CD123 in basophils
10) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.01 Pain Relevance 0.44

General Comments

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