INT182178

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.16
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DCPS) mitochondrion (DCPS) nucleolus (DCPS)
nucleus (DCPS) cytoplasm (DCPS)
Anatomy Link Frequency
CD86 2
DCs 2
DCPS (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 87 98.80 Very High Very High Very High
Inflammation 15 79.04 Quite High
corticosteroid 1 61.28 Quite High
cINOD 3 59.52 Quite High
cytokine 38 53.44 Quite High
chemokine 10 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 171 100.00 Very High Very High Very High
Rheumatoid Arthritis 87 98.80 Very High Very High Very High
Cancer 6 89.52 High High
Necrosis 9 89.04 High High
Infection 42 88.40 High High
INFLAMMATION 18 79.04 Quite High
Hookworm Infection 35 74.60 Quite High
Parasitic Infection 2 56.16 Quite High
Malaria 1 51.52 Quite High
Worm Infection 13 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the APC function of PB pDCs was less efficient than that of PB myeloid DCs, RA SF pDCs efficiently activated resting allogeneic PB T cells, and high levels of IFN-?
Regulation (efficient) of Gene_expression (function) of pDCs in DCs associated with rheumatoid arthritis
1) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.97 Pain Relevance 0.40
While this is indeed the case for matured DCs from non-infected donors, mDCs from Necator-infected individuals have a down-regulated expression of antigen-presenting, costimulatory (CD86) molecules, and CD11c, with the CD14 still present on the cell surface.
Regulation (regulated) of Gene_expression (expression) of mDCs in CD86
2) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0.12
As the MR is the major receptor responsible for FD uptake inhibited by mannose, we then assessed MR expression in SLE moDCs and in control moDCs (Figure 2a).
Regulation (control) of Gene_expression (expression) of moDCs associated with systemic lupus erythematosus
3) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.90 Pain Relevance 0
As the MR is the major receptor responsible for FD uptake inhibited by mannose, we then assessed MR expression in SLE moDCs and in control moDCs (Figure 2a).
Regulation (control) of Gene_expression (expression) of moDCs associated with systemic lupus erythematosus
4) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.89 Pain Relevance 0

General Comments

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