INT182180

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.94
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
DCs 1
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 174 98.46 Very High Very High Very High
Inflammation 20 98.04 Very High Very High Very High
cytokine 28 77.72 Quite High
Pain 4 35.12 Quite Low
Multiple sclerosis 2 31.28 Quite Low
Arthritis 2 30.08 Quite Low
psoriasis 2 29.00 Quite Low
spinal inflammation 2 26.00 Quite Low
chemokine 8 7.04 Low Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 174 98.46 Very High Very High Very High
INFLAMMATION 20 98.04 Very High Very High Very High
Disease 10 97.44 Very High Very High Very High
Necrosis 6 91.72 High High
Cancer 8 91.36 High High
Virus Diseases 2 35.48 Quite Low
Pain 4 35.12 Quite Low
Reprotox - General 1 2 32.72 Quite Low
Skin Cancer 2 31.84 Quite Low
Demyelinating Disease 2 31.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, pDCs are recruited to RA synovial tissue and comprise an APC population distinct from the previously described nuclear RelB+ synovial DCs. pDCs may contribute significantly to the local inflammatory environment.



Transcription (described) of synovial in DCs associated with inflammation and rheumatoid arthritis
1) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.97 Pain Relevance 0.39
Since the functional role of pDCs in disease pathogenesis is only partly understood, we also wished to address whether these cells represent a population distinct from the described nuclear RelB+ synovial DCs, and whether they may contribute as APCs or inflammatory cells in RA [21].


Transcription (described) of synovial associated with inflammation, rheumatoid arthritis and disease
2) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.97 Pain Relevance 0.42

General Comments

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