INT182194

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.14
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8, CXCR2) intracellular (IL8, CXCR2) extracellular space (IL8)
extracellular region (IL8) plasma membrane (CXCR2) signal transducer activity (CXCR2)
Anatomy Link Frequency
leukocyte 2
glandular epithelial cell 1
IL8 (Homo sapiens)
CXCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 391 100.00 Very High Very High Very High
opioid receptor 38 100.00 Very High Very High Very High
agonist 38 100.00 Very High Very High Very High
rheumatoid arthritis 154 97.44 Very High Very High Very High
endometriosis 70 97.28 Very High Very High Very High
Arthritis 6 93.72 High High
antagonist 29 82.00 Quite High
MU agonist 16 77.04 Quite High
Inflammation 85 72.28 Quite High
Multiple sclerosis 4 72.04 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 445 99.84 Very High Very High Very High
Choristoma 8 98.44 Very High Very High Very High
Rheumatoid Arthritis 154 97.44 Very High Very High Very High
Endometriosis 81 97.28 Very High Very High Very High
Arthritis 6 93.72 High High
Bordatella Infection 16 91.72 High High
Cancer 230 83.52 Quite High
Stomach Cancer 10 77.60 Quite High
Disease 83 72.60 Quite High
INFLAMMATION 97 72.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because IL-8 functionally interacts with CXCR2 we assessed the effect of multiple genotypes on breast carcinoma risk.
IL-8 Binding (interacts) of CXCR2 associated with breast cancer
1) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.57 Pain Relevance 0
Since CXCR2 binds to all ELR+CXC chemokines that induce angiogenesis, including IL-8, it may be safe to say that CXCR2 is a mediator of the proangiogenic effects of IL-8.
IL-8 Binding (binds) of CXCR2 associated with chemokine
2) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.47 Pain Relevance 0.09
Then we used existing and additional genotype data on 409 breast cancer cases and 301 healthy controls to examine the potential contribution of the combined genotypes of IL-8 and CXCR2 in breast carcinoma occurrence, clinico-pathological characteristics and prognosis.


IL-8 Binding (genotypes) of CXCR2 associated with breast cancer
3) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.86 Pain Relevance 0.04
Only CXCL-8/IL-8 and CXCL-6 specifically bind to CXCR1 whereas all ELR+CXC chemokines bind to CXCR2.
IL-8 Binding (bind) of CXCR2 associated with chemokine
4) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.70 Pain Relevance 0.34
Only CXCL-8/IL-8 and CXCL-6 specifically bind to CXCR1 whereas all ELR+CXC chemokines bind to CXCR2.
CXCL-8 Binding (bind) of CXCR2 associated with chemokine
5) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.70 Pain Relevance 0.34
These included CXCL13, CXCL12, CXCL8, CXCL1-3 and CXCL5, which are ligands for the chemokine receptors CXCR5, CXCR4 and CXCR2.
CXCL8 Binding (ligands) of CXCR2 associated with chemokine
6) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.25 Pain Relevance 0.95
Furthermore, glandular epithelial cell localisation and upregulation of immunoreactive CXCR1 and CXCR2, which bind CXCL8, has been demonstrated in eutopic and ectopic tissue sections from endometriosis patients when compared to controls [54].
CXCL8 Binding (bind) of CXCR2 in glandular epithelial cell associated with choristoma and endometriosis
7) Confidence 0.21 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.04 Pain Relevance 0.61
The closely related CXCR1 and CXCR2 receptors [14] share a common agonist ligand in IL-8 (interleukin 8; also called CXCL8).
IL-8 Binding (ligand) of CXCR2 associated with agonist
8) Confidence 0.12 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.14 Pain Relevance 0.68
This effect of IL-8 was blocked by the co-addition of SB225002 (Figure 4B), whereas each of DADLE, the DOP opioid receptor selective DPDPE and the highly DOP receptor selective small molecule SNC162 [28] were unable to promote binding of [35S]GTP[S] to the hCXCR2–C352I G?
IL-8 Neg (unable) Binding (binding) of hCXCR2 associated with opioid receptor
9) Confidence 0.10 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.16 Pain Relevance 0.08
IL-8/CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte chemotaxis such as polymorphonuclear neutrophils and specific T cells [41, 42].
CXCL8 Binding (ligand) of CXCR2 in leukocyte associated with chemokine
10) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.63 Pain Relevance 0.52
IL-8/CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte chemotaxis such as polymorphonuclear neutrophils and specific T cells [41, 42].
IL-8 Binding (ligand) of CXCR2 in leukocyte associated with chemokine
11) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.63 Pain Relevance 0.52

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