INT182200

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.89
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL13) extracellular space (CXCL13) extracellular region (CXCL13)
plasma membrane (CXCR5) cell-cell signaling (CXCL13) signal transducer activity (CXCR5)
Anatomy Link Frequency
synovium 1
CXCR5 (Homo sapiens)
CXCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 180 100.00 Very High Very High Very High
rheumatoid arthritis 426 99.16 Very High Very High Very High
Inflammation 33 52.04 Quite High
cytokine 12 33.72 Quite Low
antagonist 3 33.60 Quite Low
Pain 3 28.92 Quite Low
Rheumatism 3 17.52 Low Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 426 99.16 Very High Very High Very High
Syndrome 3 85.60 High High
Disease 18 63.16 Quite High
INFLAMMATION 33 52.04 Quite High
Pain 3 28.92 Quite Low
Immunodeficiency 3 28.52 Quite Low
Rheumatic Diseases 3 17.52 Low Low
Adhesions 3 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The microarrays showed that the mRNA for CXCL13, the only known ligand of CXCR5, was present in the RA synovium and not in the non-RA synovium.
CXCR5 Binding (ligand) of CXCL13 in synovium associated with rheumatoid arthritis
1) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.88 Pain Relevance 0.55
These included CXCL13, CXCL12, CXCL8, CXCL1-3 and CXCL5, which are ligands for the chemokine receptors CXCR5, CXCR4 and CXCR2.
CXCR5 Binding (ligands) of CXCL13 associated with chemokine
2) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.25 Pain Relevance 0.95
CXCL13, the unique ligand of CXCR5, is also involved in follicular homing, as observed in CXCL13-deficient mice [28].
CXCR5 Binding (ligand) of CXCL13
3) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.76 Pain Relevance 0.57

General Comments

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