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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.80
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
macrophages 1
bone marrow 1
synovium 1
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 142 100.00 Very High Very High Very High
chemokine 63 100.00 Very High Very High Very High
cytokine 16 84.08 Quite High
cva 50 80.96 Quite High
Inflammation 21 80.88 Quite High
Hippocampus 10 77.04 Quite High
Inflammatory response 3 67.40 Quite High
ischemia 8 14.40 Low Low
tolerance 1 12.24 Low Low
anesthesia 6 6.64 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 161 100.00 Very High Very High Very High
Coronary Artery Disease 66 99.16 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 73 95.52 Very High Very High Very High
Infection 30 94.56 High High
Sprains And Strains 2 93.20 High High
Apoptosis 25 89.04 High High
Cancer 62 87.04 High High
Death 19 86.48 High High
Pancreatic Cancer 24 83.36 Quite High
Cv General 4 Under Development 41 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, the presence of GM-CSF suppresses the expression of CXCR4 mRNA and CCR5 mRNA by monocytes differentiating in macrophages, resulting in macrophages that are relatively resistant to M-tropic HIV infection [25].
Transcription (expression) of CXCR4 in macrophages associated with acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.69 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.91 Pain Relevance 0.03
In the present study mRNA for other chemokine receptors were detected in the RA synovium, such as CXCR1, CXCR2, CXCR4, Bob, CCR1, CCR2a, CCR7, CCR9 and CX3CR1 (CXCR3 was not on the microarray).
Neg (not) Transcription (detected) of CXCR4 in synovium associated with chemokine and rheumatoid arthritis
2) Confidence 0.59 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.45 Pain Relevance 0.47
In addition to growth factors, the RT-PCR study has demonstrated that both primary human MSCs and B10 cells express mRNA for VEGFR, CXCR4 and c-kit, cellular receptors known for close involvement in cellular migration (Figure 10).
Transcription (express) of CXCR4
3) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.20 Pain Relevance 0.18
In a recent study, hepatic regeneration was induced by treating rats with 2-acetylaminofluorene and followed by partial hepatectomy.31 CXCR4 mRNA expression, assessed by both quantitative RT-PCR and in situ hybridization, was increased during hepatic regeneration.
Spec (partial) Transcription (expression) of CXCR4
4) Confidence 0.43 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.20 Pain Relevance 0.22
In this study, no difference in CXCR4 mRNA expression in CD34+ cells from CAD patients was observed.
Transcription (expression) of CXCR4 associated with coronary artery disease
5) Confidence 0.38 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.45 Pain Relevance 0
They also suppress the transcription of the chemokine (CXCR4) encoding gene that plays a pivotal role in both the differentiation of endothelial cells in the bone marrow and their mobilization [39].
Transcription (transcription) of CXCR4 in bone marrow associated with chemokine
6) Confidence 0.22 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.58 Pain Relevance 0.05

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