INT182213

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 10.00
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR5) signal transducer activity (CXCR5)
Anatomy Link Frequency
synovium 3
blood 1
macrophage 1
leukocytes 1
B cells 1
CXCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 704 100.00 Very High Very High Very High
rheumatoid arthritis 1402 99.84 Very High Very High Very High
Inflammation 135 99.10 Very High Very High Very High
Osteoarthritis 38 89.12 High High
Infliximab 2 81.76 Quite High
Etanercept 2 80.80 Quite High
Adalimumab 2 79.60 Quite High
cINOD 6 69.84 Quite High
cytokine 38 8.76 Low Low
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1402 99.84 Very High Very High Very High
INFLAMMATION 137 99.10 Very High Very High Very High
Disease 72 96.08 Very High Very High Very High
Osteoarthritis 49 89.12 High High
Systemic Lupus Erythematosus 78 87.00 High High
Frailty 9 86.40 High High
Autoimmune Disease 4 85.64 High High
Cancer 4 84.80 Quite High
Necrosis 4 84.32 Quite High
Immunodeficiency 9 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the CXCR5 mRNA is expressed at similar levels in RA PB and RA SF it is suggested that the contribution of monocytes/macrophages to the upregulation of CXCR5 in the RA synovium is due to their increased number, rather than due to an increased abundance of CXCR5 transcripts per cell.
Positive_regulation (upregulation) of CXCR5 in synovium associated with rheumatoid arthritis
1) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.10 Pain Relevance 0.62
The major finding of the present study is that CXCR5 is upregulated in the RA synovium.
Positive_regulation (upregulated) of CXCR5 in synovium associated with rheumatoid arthritis
2) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.85 Pain Relevance 0.47
Chemokine receptors in the rheumatoid synovium: upregulation of CXCR5

In patients with rheumatoid arthritis (RA), chemokine and chemokine receptor interactions play a central role in the recruitment of leukocytes into inflamed joints.

Positive_regulation (upregulation) of CXCR5 in leukocytes associated with chemokine and rheumatoid arthritis
3) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1065316 Disease Relevance 0.99 Pain Relevance 0.72
Intimal cells were widely positive for CXCR5 and serial sections indicated that these included CD68+ macrophage-like cells (Fig. 5a,5b).
Positive_regulation (positive) of CXCR5 in macrophage
4) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.56 Pain Relevance 0.28
More importantly, the increased level of CXCR5, a homeostatic chemokine receptor, in the RA synovium suggests that non-inflammatory receptor–ligand pairs might play an important role in the pathogenesis of RA.



Positive_regulation (increased) of CXCR5 in synovium associated with chemokine, inflammation and rheumatoid arthritis
5) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.00 Pain Relevance 0.65
These results indicated that, of the chemokine receptors studied, CXCR5 was the most upregulated in RA (Table 3).
Positive_regulation (upregulated) of CXCR5 associated with chemokine and rheumatoid arthritis
6) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.27 Pain Relevance 0.79
The expression of a marker shared by cells that are known to play a central role in the process of chronic inflammation is of particular interest and suggests that targeting CXCR5 could provide a powerful new treatment for RA.


Positive_regulation (targeting) of CXCR5 associated with inflammation and rheumatoid arthritis
7) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.76 Pain Relevance 0.48
The present study shows that CXCR5 is upregulated in RA synovial tissue and is expressed in a variety of cell types.
Positive_regulation (upregulated) of CXCR5 associated with rheumatoid arthritis
8) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.20 Pain Relevance 0.74
This feature may be responsible for the particular upregulation of the constitutive chemokine receptor CXCR5.
Positive_regulation (upregulation) of CXCR5 associated with chemokine
9) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.81 Pain Relevance 0.60
The analysis of chemokine receptor expression showed that the majority of peripheral blood B cells is positive for CXCR3, CXCR4, CXCR5, CCR6 and CCR7.
Positive_regulation (positive) of CXCR5 in blood associated with chemokine
10) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 0.97 Pain Relevance 0.51
In three of the samples, B cells showed a pattern of chemokine receptor expression as described above, in that the median value for the frequency of B cells with high levels of CXCR5 was decreased from 93.8% (range 66.9 to 99.3%) to 79.4% (range 2.6 to 96.8%) (Fig. 10).
Positive_regulation (levels) of CXCR5 in B cells associated with chemokine
11) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.49 Pain Relevance 0.51

General Comments

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