INT182215

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.49
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR5) signal transducer activity (CXCR5)
Anatomy Link Frequency
monocytes 1
B-cells 1
T cells 1
CXCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 180 100.00 Very High Very High Very High
rheumatoid arthritis 426 99.84 Very High Very High Very High
antagonist 3 98.72 Very High Very High Very High
Rheumatism 3 81.36 Quite High
Inflammation 33 74.56 Quite High
intrathecal 5 70.60 Quite High
cytokine 12 56.24 Quite High
Pain 4 51.44 Quite High
Central nervous system 1 43.72 Quite Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 426 99.84 Very High Very High Very High
Infection 18 98.78 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 37 98.58 Very High Very High Very High
Disease 23 96.32 Very High Very High Very High
Lyme Neuroborreliosis 27 95.92 Very High Very High Very High
Immunodeficiency 4 88.56 High High
Syndrome 3 86.72 High High
Rheumatic Diseases 3 81.36 Quite High
Lyme Disease 11 77.44 Quite High
INFLAMMATION 33 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCR5 is a chemokine receptor highly expressed in recirculating B cells, in subsets of CD4+ and CD8+ T cells and monocytes [20,21].
Regulation (receptor) of CXCR5 in T cells associated with chemokine
1) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.99 Pain Relevance 0.81
Our study identifies CXCR5 as a potentially interesting therapeutic target in RA and points to the use of antagonists to this receptor as a treatment strategy in the disease.


Regulation (target) of CXCR5 associated with antagonist, rheumatoid arthritis and disease
2) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.93 Pain Relevance 0.52
In HIV infection the levels of CXCL13 in serum are elevated and the receptor CXCR5 on B-cells is down regulated causing impaired trafficking of B-cells [10].
Regulation (regulated) of CXCR5 in B-cells associated with acquired immune deficiency syndrome or hiv infection and infection
3) Confidence 0.11 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3009961 Disease Relevance 1.58 Pain Relevance 0.04
CXCR5 is a chemokine receptor highly expressed in recirculating B cells, in subsets of CD4+ and CD8+ T cells and monocytes [20,21].
Regulation (receptor) of CXCR5 in monocytes associated with chemokine
4) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.99 Pain Relevance 0.81

General Comments

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