INT182217

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 7
Reported most in Body
Documents 8
Total Number 54
Disease Relevance 44.81
Pain Relevance 18.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR9) signal transducer activity (CCR9)
Anatomy Link Frequency
monocytes 16
macrophages 11
T cells 3
blood 2
B cells 2
CCR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1681 100.00 Very High Very High Very High
rheumatoid arthritis 5089 99.84 Very High Very High Very High
cytokine 246 99.40 Very High Very High Very High
Inflammation 536 99.08 Very High Very High Very High
antagonist 143 91.48 High High
Osteoarthritis 38 87.36 High High
Etanercept 47 73.92 Quite High
methotrexate 90 72.96 Quite High
Leflunomide 45 71.84 Quite High
psoriasis 7 67.56 Quite High
Disease Link Frequency Relevance Heat
Cancer 180 100.00 Very High Very High Very High
Rheumatoid Arthritis 5944 99.84 Very High Very High Very High
Acute Monocytic Leukemia 90 99.60 Very High Very High Very High
Inflammatory Bowel Disease 47 99.46 Very High Very High Very High
Reprotox - General 1 45 99.20 Very High Very High Very High
Disease 782 99.08 Very High Very High Very High
Leukemia 45 99.08 Very High Very High Very High
INFLAMMATION 449 98.88 Very High Very High Very High
Necrosis 94 98.76 Very High Very High Very High
Neurological Disease 52 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore we examined the expression and function of CCR9 by monocytes and macrophages in RA.


Spec (examined) Gene_expression (expression) of CCR9 in monocytes associated with rheumatoid arthritis
1) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.25 Pain Relevance 0.50
It is unknown, as yet, whether CCR9 is modulated during monocyte differentiation and differentially expressed by polarized (M1 and M2) macrophages, together with the effect of CCL25 on markers of macrophage polarization.
Gene_expression (expressed) of CCR9 in macrophage
2) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.45 Pain Relevance 0.27
Therefore CCR9 has mainly been reported to function in lymphocyte migration although other cell types, such as tumour cells, can express CCR9, playing a role in prostate cancer cell migration and invasion [22].
Gene_expression (express) of CCR9 in lymphocyte associated with cancer and reprotox - general 1
3) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.87 Pain Relevance 0.39
CCR9 mRNA was expressed in isolated RA monocytes/macrophages from both PB and SF (Figure 3b).
Gene_expression (expressed) of CCR9 mRNA in monocytes associated with rheumatoid arthritis
4) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.80 Pain Relevance 0.43
Therefore the increase in the expression of CCR9 may be related to the enhanced activation state of monocytes/macrophages in the RA circulation and synovial tissue.
Gene_expression (expression) of CCR9 in macrophages associated with rheumatoid arthritis
5) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.50 Pain Relevance 0.32
CCR9 expression in synovium
Gene_expression (expression) of CCR9 in synovium
6) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.81 Pain Relevance 0.45
This cytokine elicited an up-regulation of CCR9 expression as shown by flow cytometry (P < 0.01).
Gene_expression (expression) of CCR9 associated with cytokine
7) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.39 Pain Relevance 0.30
CCR9 is reported as a receptor on lymphoid cells and is expressed both constitutively and in inflammation.
Gene_expression (expressed) of CCR9 associated with inflammation
8) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.88 Pain Relevance 0.54
The levels of CCR9 on CD14+ monocytes in the same RA PB and healthy PB samples were compared with other chemokine receptors.
Gene_expression (levels) of CCR9 in monocytes associated with chemokine and rheumatoid arthritis
9) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.88 Pain Relevance 0.49
CCR9 expression was examined by immunohistochemistry on paraffin embedded synovial sections.
Spec (examined) Gene_expression (expression) of CCR9
10) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.91 Pain Relevance 0.50
CCR9 was also detected in non-RA samples however only in four out of seven patients.
Gene_expression (detected) of CCR9 associated with rheumatoid arthritis
11) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.89 Pain Relevance 0.45
results in increased CCR9 expression.
Gene_expression (expression) of CCR9
12) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.42 Pain Relevance 0.28
In order to quantitate differences in CCR9 expression by macrophages in RA and non-RA synovia, the number of CCR9+, CD14+ cells and CCR9+/CD14+ cells were counted in the sublining layer (Table 1).
Gene_expression (expression) of CCR9 in macrophages associated with rheumatoid arthritis
13) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.10 Pain Relevance 0.55
To further investigate whether macrophages are themselves producing CCR9 and confirm the flow cytometric results, we performed RT-PCR on monocytes/macrophages isolated from PB and SF of four RA patients and PB of nine healthy volunteers.
Gene_expression (producing) of CCR9 in macrophages associated with rheumatoid arthritis
14) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.90 Pain Relevance 0.48
Detection of CCR9 was with donkey anti-goat Alexa 594 and the other primary antibodies with goat anti-mouse Alexa 488 secondary antibodies, containing 10% human serum.
Gene_expression (Detection) of CCR9
15) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0 Pain Relevance 0
CCR9 was consistently observed in the CD14+ monocyte population and in the two subpopulations in both RA and healthy samples, examples of RA CCR9 and isotype control plots are shown in Figure 1a.
Gene_expression (observed) of CCR9 in monocyte associated with rheumatoid arthritis
16) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.89 Pain Relevance 0.40
RT-PCR analysis of CCR9
Gene_expression (analysis) of CCR9
17) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.09 Pain Relevance 0.54
Functional aspects of monocyte CCR9
Gene_expression (aspects) of CCR9 in monocyte
18) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.25 Pain Relevance 0.23
The detection of CCR7 and CCR9 in RA was only possible after extended exposure times, but at the time points used for quantification no regulation was demonstrated.
Gene_expression (detection) of CCR9 associated with rheumatoid arthritis
19) Confidence 0.63 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.08 Pain Relevance 0.73
increased CCR9 expression on human acute monocytic leukemia cell line THP-1 monocytic cells.
Gene_expression (expression) of CCR9 in THP-1 associated with acute monocytic leukemia
20) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945064 Disease Relevance 1.65 Pain Relevance 0.17

General Comments

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