INT182223

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Context Info
Confidence 0.76
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 57
Total Number 59
Disease Relevance 51.49
Pain Relevance 28.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR5) signal transducer activity (CXCR5)
Anatomy Link Frequency
B cells 16
T cells 7
macrophages 5
plasma cells 4
monocytes 3
CXCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6574 100.00 Very High Very High Very High
chemokine 3840 100.00 Very High Very High Very High
Osteoarthritis 361 99.88 Very High Very High Very High
Inflammation 774 90.96 High High
antagonist 38 80.80 Quite High
cytokine 189 69.76 Quite High
Rheumatism 38 64.72 Quite High
Pain 38 51.44 Quite High
cINOD 57 51.12 Quite High
Adalimumab 19 23.72 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 6574 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 741 99.90 Very High Very High Very High
Osteoarthritis 418 99.88 Very High Very High Very High
Disease 403 98.44 Very High Very High Very High
Hypergammaglobulinemia 2 95.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 94.72 High High
Autoimmune Disease 38 92.16 High High
Infection 92 91.68 High High
INFLAMMATION 793 90.96 High High
Syndrome 38 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study the expression of CXCR5 and CXCR4 was 22.6 ± 0.7-fold higher and 3.5 ± 0.1-fold higher in RA tissue than in non-RA tissue, respectively.
Gene_expression (expression) of CXCR5 associated with rheumatoid arthritis
1) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.23 Pain Relevance 0.73
Consequently, RT-PCR was performed to verify that RA macrophages/monocytes can express CXCR5.
Gene_expression (express) of CXCR5 in monocytes associated with rheumatoid arthritis
2) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.15 Pain Relevance 0.57
Immunohistochemical experiments indicated that CD68+ cells in the synovial intima express CXCR5.
Gene_expression (express) of CXCR5
3) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.74 Pain Relevance 0.32
The increased numbers of B lymphocytes, T lymphocytes and macrophages producing CXCR5 in the RA synovium are probably responsible for the increased expression of the receptor in this chronically inflamed tissue.
Gene_expression (producing) of CXCR5 in macrophages associated with rheumatoid arthritis
4) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.88 Pain Relevance 0.52
The expression of CXCR5 has been reported in mature B cells and secondary lymphoid organs but as far as the authors are aware this is the first report of a chemokine receptor expressed by B cells in the RA synovium and its ectopic lymphoid structures.
Gene_expression (expression) of CXCR5 in mature B cells associated with chemokine and rheumatoid arthritis
5) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.86 Pain Relevance 0.52
Endothelial cells are another cell type expressing CXCR5 in the synovium.
Gene_expression (expressing) of CXCR5 in synovium
6) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.83 Pain Relevance 0.73
CD3 expression alone gave a light red colour (Fig. 3e) and CXCR5 expression alone produced a grey–black colour (Fig. 3f).
Gene_expression (expression) of CXCR5
7) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.30 Pain Relevance 0.15
Using this technique it was evident that in the RA synovium there was a population of CD3+ T cells that expressed CXCR5 (Fig. 3f).
Gene_expression (expressed) of CXCR5 in T cells associated with rheumatoid arthritis
8) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.44 Pain Relevance 0.22
CXCR5 is a chemokine receptor highly expressed in recirculating B cells, in subsets of CD4+ and CD8+ T cells and monocytes [20,21].
Gene_expression (expressed) of CXCR5 in T cells associated with chemokine
9) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.99 Pain Relevance 0.81
These cell aggregates contained CD20+ B cells that expressed CXCR5.
Gene_expression (expressed) of CXCR5 in B cells
10) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.80 Pain Relevance 0.48
The microarray and RT-PCR experiments demonstrated the differential expression of CXCR5, and immunohistochemistry showed that this receptor is expressed in B-cell and T-cell infiltrates, on macrophages and blood vessels.
Gene_expression (expression) of CXCR5 in T-cell
11) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.83 Pain Relevance 0.54
In the normal non-RA intima, macrophages are positive for CD68 and fibroblasts are negative, making it more certain that macrophages express CXCR5 in this cell layer [45].
Gene_expression (express) of CXCR5 in macrophages associated with rheumatoid arthritis
12) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.08 Pain Relevance 0.51
PCR experiments confirmed the differential expression of CXCR5.
Gene_expression (expression) of CXCR5
13) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.17 Pain Relevance 0.77
The endothelial cells of synovial postcapillary venules were positive for CXCR5 in the RA synovium (Fig. 4e).
Gene_expression (positive) of CXCR5 in synovium associated with rheumatoid arthritis
14) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.54 Pain Relevance 0.27
In the RA samples the presence of CXCR5 was observed on B cells and T cells in the infiltrates but also on macrophages and endothelial cells.
Gene_expression (presence) of CXCR5 in T cells associated with rheumatoid arthritis
15) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.23 Pain Relevance 0.82
Therefore, since macrophages are abundant in the RA intima and because of their strong reactivity with anti-CD68, it is likely that intimal macrophages are positive for CXCR5.
Gene_expression (positive) of CXCR5 in macrophages associated with rheumatoid arthritis
16) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.06 Pain Relevance 0.49
These were CCR1, CCR2a, CCR5, CCR7, CCR9, CX3CR1, CXCR1, CXCR2, CXCR4, CXCR5, CXCR6 (STRL33) and Bob (Table 3).
Gene_expression (These) of CXCR5
17) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.13 Pain Relevance 0.85
RT-PCR analysis of CXCR5
Gene_expression (analysis) of CXCR5
18) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.59 Pain Relevance 0.45
In patients with SLE, significant changes in CXCR5 expression were seen.
Gene_expression (expression) of CXCR5 associated with systemic lupus erythematosus
19) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 0.96 Pain Relevance 0.57
However, neither in patients with RA nor in patients with SLE did we see a significant correlation in the expression of CXCR5 and CXCR4.
Gene_expression (expression) of CXCR5 associated with rheumatoid arthritis and systemic lupus erythematosus
20) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.84 Pain Relevance 0.40

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