INT182224

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.91
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
MALT 1
skin 1
synovium 1
T-cell 1
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 154 100.00 Very High Very High Very High
rheumatoid arthritis 271 99.98 Very High Very High Very High
chemokine 101 99.76 Very High Very High Very High
cytokine 52 85.24 High High
Inflammation 50 84.84 Quite High
ischemia 3 67.56 Quite High
Crohn's disease 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
abatacept 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 144 100.00 Very High Very High Very High
Rheumatoid Arthritis 273 99.98 Very High Very High Very High
Injury 21 99.54 Very High Very High Very High
Lymphatic System Cancer 122 99.40 Very High Very High Very High
Sialadenitis 3 99.02 Very High Very High Very High
Salivary Gland Disease 2 98.20 Very High Very High Very High
Malignant Neoplastic Disease 8 95.16 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 87.20 High High
INFLAMMATION 51 84.84 Quite High
Adhesions 20 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found no significant association with the SNPs in the MMEL, CDK6, CCL21 or the CD40 genes, which may suggest that these genes are RA-specific loci.
CCL21 Neg (no) Binding (association) of associated with rheumatoid arthritis
1) Confidence 0.34 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.90 Pain Relevance 0.45
However, as the effect sizes for these genes in RA were modest, this study had limited power to detect an association with JIA and MMEL, CDK6 and CCL21 (53%, 69% and 59% respectively).
CCL21 Binding (association) of associated with rheumatoid arthritis and arthritis
2) Confidence 0.34 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.91 Pain Relevance 0.45
Several chemokines were visible on RA microarrays but not on non-RA microarrays (namely CXCL13, CCL21 and CCL24), suggesting that these genes might be induced in the inflamed synovium.
CCL21 Binding (microarrays) of in synovium associated with chemokine and rheumatoid arthritis
3) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.18 Pain Relevance 0.95
Keratinocytes within sites of wounded skin have been reported to express CCL21 [41], and MSCs, characterized to express the CCL21-specific receptor CCR7, were reported to recruit to the wound site via the specific CCL21/CCR7 interaction, both in vitro and in vivo [40].
CCL21 Binding (interaction) of in skin associated with injury
4) Confidence 0.16 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.54 Pain Relevance 0.03
Conversely, CCL19, CCL21 and their associated receptor CCR7 contribute to the accumulation of mature DCs in T-cell-rich areas of lymphoid organs and to the formation of germinal centres [31].
CCL21 Binding (associated) of in T-cell
5) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.54 Pain Relevance 0.48
Barone et al. showed that, within salivary glands with lymphoepithelial sialadenitis (LESA) and MALT lymphoma, the lymphoid CKs CXCL13 and CCL21 are selectively associated with areas of reactive lymphoid proliferation, whereas no significant expression of these molecules was detected in the malignant lymphoid aggregate.
CCL21 Binding (associated) of in MALT associated with chemokine, malignant neoplastic disease, lymphatic system cancer, salivary gland disease and sialadenitis
6) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.85 Pain Relevance 0.18

General Comments

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