INT182228

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Context Info
Confidence 0.79
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 6.17
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR5) signal transducer activity (CXCR5)
Anatomy Link Frequency
endothelial cells 2
macrophages 1
B cells 1
T cells 1
CXCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 994 99.82 Very High Very High Very High
chemokine 420 90.88 High High
Inflammation 77 57.20 Quite High
imagery 7 29.36 Quite Low
cytokine 28 13.08 Low Low
Rheumatism 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 994 99.82 Very High Very High Very High
Frailty 7 70.00 Quite High
INFLAMMATION 77 57.20 Quite High
Disease 42 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Syndrome 7 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low
Immunodeficiency 7 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Rheumatic Diseases 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was not possible to colocalize CXCR5 and CD3 in serial sections, so a double-label immunohistochemistry technique was developed.
Localization (colocalize) of CXCR5
1) Confidence 0.79 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.46 Pain Relevance 0.23
Immunohistochemistry for CXCR5
Localization (Immunohistochemistry) of CXCR5
2) Confidence 0.73 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.07 Pain Relevance 0.04
In non-RA tissue, CXCR5 was localized in the intima and endothelial cells (Fig. 5).
Localization (localized) of CXCR5 in endothelial cells associated with rheumatoid arthritis
3) Confidence 0.69 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.56 Pain Relevance 0.28
In the non-RA samples the presence of CXCR5 was limited to macrophages and endothelial cells.
Localization (presence) of CXCR5 in macrophages associated with rheumatoid arthritis
4) Confidence 0.69 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.32 Pain Relevance 0.86
In the RA samples the presence of CXCR5 was observed on B cells and T cells in the infiltrates but also on macrophages and endothelial cells.
Localization (presence) of CXCR5 in T cells associated with rheumatoid arthritis
5) Confidence 0.69 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.23 Pain Relevance 0.82
In the non-RA samples the presence of CXCR5 was limited to macrophages and endothelial cells.
Localization (presence) of CXCR5 in endothelial cells associated with rheumatoid arthritis
6) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.32 Pain Relevance 0.86
In the RA samples the presence of CXCR5 was observed on B cells and T cells in the infiltrates but also on macrophages and endothelial cells.
Localization (presence) of CXCR5 in B cells associated with rheumatoid arthritis
7) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.23 Pain Relevance 0.82

General Comments

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