INT182229

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 12.19
Pain Relevance 8.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL16) extracellular region (CCL16) cell-cell signaling (CCL16)
Anatomy Link Frequency
basement membrane 1
epithelium 1
synovium 1
glands 1
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 756 100.00 Very High Very High Very High
cytokine 71 100.00 Very High Very High Very High
rheumatoid arthritis 568 99.84 Very High Very High Very High
Morphine 50 99.84 Very High Very High Very High
endometriosis 490 99.80 Very High Very High Very High
Inflammation 168 98.94 Very High Very High Very High
Chronic pancreatitis 33 86.36 High High
Inflammatory mediators 7 75.00 Quite High
antagonist 7 63.64 Quite High
opioid receptor 15 63.20 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 568 99.84 Very High Very High Very High
Endometriosis 567 99.80 Very High Very High Very High
Capsule Opacification 192 99.68 Very High Very High Very High
Primary Sclerosing Cholangitis 77 99.44 Very High Very High Very High
Cataract 88 99.36 Very High Very High Very High
INFLAMMATION 192 98.94 Very High Very High Very High
Disease 67 94.88 High High
Sepsis 15 90.28 High High
Cyst 21 88.40 High High
Pancreatitis 33 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in women with endometriosis, eutopic CCL16 and CCL21 mRNA levels were increased in some subjects but with significant patient-to-patient variability.
Positive_regulation (increased) of CCL16 associated with endometriosis
1) Confidence 0.66 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.59 Pain Relevance 0.33
CXCL8 (IL-8), another chemokine whose mRNA was increased in endometrial glands from women with endometriosis in our array study, has previously been studied in depth with regard to a role in endometriosis [51], further substantiating our gene array results.
Positive_regulation (increased) of chemokine in glands associated with endometriosis and chemokine
2) Confidence 0.58 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.19 Pain Relevance 0.53
This data supports the hypothesis that the inflammatory phenotype observed in endometriosis may involve the activation of chemokine cascades.


Positive_regulation (activation) of chemokine associated with chemokine, endometriosis and inflammation
3) Confidence 0.58 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.72 Pain Relevance 0.53
This data thus adds CCL16 and CCL21 to the chemokines found to be elevated in endometriosis supporting a role for chemokines in the pathogenesis of endometriosis.
Positive_regulation (adds) of CCL16 associated with endometriosis and chemokine
4) Confidence 0.48 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.59 Pain Relevance 0.55
Since the findings from the cDNA array and real time RT-PCR experiments supported a role for CCL21 and CCL16 in at least some women with endometriosis, immunohistochemistry was performed to establish the presence and cellular location of the protein for these 2 chemokines in eutopic and ectopic endometrial samples.
Positive_regulation (role) of CCL16 associated with chemokine and endometriosis
5) Confidence 0.48 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.66 Pain Relevance 0.47
22 chemokine/receptor genes were upregulated and two downregulated in pooled endometrial epithelium of women with endometriosis compared with controls.
Positive_regulation (upregulated) of chemokine in epithelium associated with endometriosis and chemokine
6) Confidence 0.39 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1884154 Disease Relevance 0.66 Pain Relevance 0.55
CCL16 and CCL21 mRNA was confirmed as elevated in some women with endometriosis compared to controls on individual samples.
Positive_regulation (elevated) of CCL16 associated with endometriosis
7) Confidence 0.19 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1884154 Disease Relevance 0.64 Pain Relevance 0.53
As previously demonstrated [27], when assessed by the TRAP assay, telomerase activity was significantly (p<0.05) increased in LEC that were exposed to irradiation and allowed to recover for 24 h (Figure 2C).
Positive_regulation (increased) of LEC
8) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.19 Pain Relevance 0
One recent study has found that induction of the PDGF pathway in human LEC resulted in a PI3K/Akt pathway dependent increase in cellular migration [21].
Positive_regulation (induction) of LEC
9) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.56 Pain Relevance 0
M celecoxib for two weeks also had vacuolated LEC that did not adhere to the underlying basement membrane (Figure 8A,B).
Positive_regulation (vacuolated) of LEC in basement membrane
10) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.21 Pain Relevance 0
This finding suggests that pAkt and TERT may be necessary at an initial step for EMT to occur in LEC during PCO and cataract formation.
Positive_regulation (occur) of LEC associated with capsule opacification and cataract
11) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.77 Pain Relevance 0
As shown in figure 1, of the chemokines studied, only CCL2 mRNA was expressed constitutively and this was the only chemokine mRNA that was significantly upregulated by morphine exposure.
Positive_regulation (upregulated) of chemokine associated with chemokine and morphine
12) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 0.98
These results indicated that, of the chemokine receptors studied, CXCR5 was the most upregulated in RA (Table 3).
Positive_regulation (upregulated) of chemokine associated with chemokine and rheumatoid arthritis
13) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.28 Pain Relevance 0.79
This feature may be responsible for the particular upregulation of the constitutive chemokine receptor CXCR5.
Positive_regulation (upregulation) of chemokine associated with chemokine
14) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.81 Pain Relevance 0.60
The upregulation of CXCL9 in RA synovia is in agreement with the only microarray study of RA synovia, in which this chemokine was also shown to be increased [31].
Positive_regulation (increased) of chemokine associated with chemokine and rheumatoid arthritis
15) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.12 Pain Relevance 0.96
More importantly, the increased level of CXCR5, a homeostatic chemokine receptor, in the RA synovium suggests that non-inflammatory receptor–ligand pairs might play an important role in the pathogenesis of RA.



Positive_regulation (increased) of chemokine in synovium associated with chemokine, inflammation and rheumatoid arthritis
16) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065316 Disease Relevance 1.01 Pain Relevance 0.65
Cytokine and chemokine mRNA expression levels were subsequently evaluated in PBMC and PSC to determine the source of increased cytokine/chemokine levels in cell culture supernatants.
Positive_regulation (increased) of chemokine associated with chemokine, primary sclerosing cholangitis and cytokine
17) Confidence 0.01 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.20 Pain Relevance 0.74

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