INT182230

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.32
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR9) signal transducer activity (CCR9)
Anatomy Link Frequency
intestine 1
CCR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 123 99.78 Very High Very High Very High
rheumatoid arthritis 351 99.60 Very High Very High Very High
antagonist 13 98.68 Very High Very High Very High
Inflammation 47 97.48 Very High Very High Very High
cytokine 25 67.32 Quite High
methotrexate 4 61.72 Quite High
psoriasis 7 59.08 Quite High
Pain 4 46.72 Quite Low
tolerance 3 46.24 Quite Low
Etanercept 2 27.52 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 389 99.60 Very High Very High Very High
Disease 62 99.24 Very High Very High Very High
INFLAMMATION 44 97.48 Very High Very High Very High
Reprotox - General 1 2 96.88 Very High Very High Very High
Cancer 43 94.52 High High
Immunodeficiency 1 93.92 High High
Inflammatory Bowel Disease 4 90.44 High High
Leukemia 2 89.32 High High
Immune System Diseases 1 88.72 High High
Herpes Simplex Virus 2 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR9 is reported as a receptor on lymphoid cells and is expressed both constitutively and in inflammation.
CCR9 Binding (receptor) of associated with inflammation
1) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.82 Pain Relevance 0.54
Contrary to many other chemokine receptors CCR9 binds only one known ligand, CCL25/TECK.
CCR9 Binding (binds) of associated with chemokine
2) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.95 Pain Relevance 0.39
Expression of the same receptors could be observed on the non-RA membranes with the exception of Bob, CCR7 and CCR9.
CCR9 Neg (exception) Binding (exception) of associated with rheumatoid arthritis
3) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.19 Pain Relevance 0.88
The administration of a small molecule antagonist of CCR9 reduces the disease severity in mouse models by blocking CCR9+ T cell migration to the intestine (M Walters, ChemoCentryx).
CCR9 Binding (migration) of in intestine associated with antagonist and disease
4) Confidence 0.14 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.36 Pain Relevance 0.38

General Comments

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