INT182231

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.35
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR5) signal transducer activity (CXCR5)
Anatomy Link Frequency
B-cells 7
macrophages 4
plasma cells 2
T lymphocytes 1
CXCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 550 99.68 Very High Very High Very High
chemokine 346 96.28 Very High Very High Very High
Osteoarthritis 38 79.16 Quite High
Inflammation 83 70.16 Quite High
cytokine 32 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Rheumatism 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 78 99.90 Very High Very High Very High
Rheumatoid Arthritis 550 99.68 Very High Very High Very High
Hypergammaglobulinemia 2 95.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 94.72 High High
Infection 92 92.08 High High
Osteoarthritis 43 79.16 Quite High
Disease 40 78.08 Quite High
Autoimmune Disease 4 75.36 Quite High
INFLAMMATION 85 70.16 Quite High
Hyperplasia 4 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with RA and patients with SLE the expression of CXCR5 on peripheral blood plasma cells was reduced to 39.3% (range 5.7 to 91.9%) and 45.6% (range 11.0 to 88.6%), respectively (Fig. 3).
Negative_regulation (reduced) of Gene_expression (expression) of CXCR5 in plasma cells associated with rheumatoid arthritis and systemic lupus erythematosus
1) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 1.19 Pain Relevance 0.41
The increased numbers of B lymphocytes, T lymphocytes and macrophages producing CXCR5 in the RA synovium are probably responsible for the increased expression of the receptor in this chronically inflamed tissue.
Negative_regulation (numbers) of Gene_expression (producing) of CXCR5 in macrophages associated with rheumatoid arthritis
2) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.90 Pain Relevance 0.53
In comparison with healthy individuals, in patients with RA a significant fraction of B cells showed a decreased expression of CXCR5 and CCR6 and increased levels of CXCR3.
Negative_regulation (decreased) of Gene_expression (expression) of CXCR5 in B cells associated with rheumatoid arthritis
3) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 1.04 Pain Relevance 0.59
More recently, Cagigi et al have shown that the decrease in CXCR5 expression is concomitant to abnormal CXCL13 production by peripheral and lymph node B-cells and increased B-cell responsiveness to CXCL13 in HIV-1 infected patients with low CD4+ T-cells counts [9].
Negative_regulation (decrease) of Gene_expression (expression) of CXCR5 in B-cell associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.81 Pain Relevance 0.04
Decreased expression of CXCR5 on blood B-cells [7] but increased proportions of CD38-expressing B-cells have been described as a consequence of abnormal trafficking of germinal centre (GC)-like B-cells into blood [8].
Negative_regulation (Decreased) of Gene_expression (expression) of CXCR5 in B-cells
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.60 Pain Relevance 0.03
The increased numbers of B lymphocytes, T lymphocytes and macrophages producing CXCR5 in the RA synovium are probably responsible for the increased expression of the receptor in this chronically inflamed tissue.
Negative_regulation (numbers) of in T lymphocytes Gene_expression (producing) of CXCR5 in macrophages associated with rheumatoid arthritis
6) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.90 Pain Relevance 0.53
The increased numbers of B lymphocytes, T lymphocytes and macrophages producing CXCR5 in the RA synovium are probably responsible for the increased expression of the receptor in this chronically inflamed tissue.
Negative_regulation (numbers) of in B lymphocytes Gene_expression (producing) of CXCR5 in macrophages associated with rheumatoid arthritis
7) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.90 Pain Relevance 0.53

General Comments

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