INT182238

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.32
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL13) extracellular space (CXCL13) extracellular region (CXCL13)
cell-cell signaling (CXCL13)
Anatomy Link Frequency
B cell 1
MALT 1
articular cartilage 1
synovium 1
CXCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 144 99.98 Very High Very High Very High
chemokine 72 99.98 Very High Very High Very High
Osteoarthritis 50 99.58 Very High Very High Very High
intrathecal 24 99.08 Very High Very High Very High
Multiple sclerosis 74 97.84 Very High Very High Very High
Inflammation 51 95.24 Very High Very High Very High
metalloproteinase 27 87.04 High High
cytokine 9 83.60 Quite High
imagery 40 70.12 Quite High
Nerve growth factor 1 64.72 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 147 99.98 Very High Very High Very High
Lymphatic System Cancer 122 99.62 Very High Very High Very High
Osteoarthritis 53 99.58 Very High Very High Very High
Sialadenitis 3 99.24 Very High Very High Very High
Syndrome 88 98.46 Very High Very High Very High
Salivary Gland Disease 2 98.42 Very High Very High Very High
Demyelinating Disease 79 97.84 Very High Very High Very High
INFLAMMATION 47 95.24 Very High Very High Very High
Malignant Neoplastic Disease 8 95.16 Very High Very High Very High
Disease 62 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several chemokines were visible on RA microarrays but not on non-RA microarrays (namely CXCL13, CCL21 and CCL24), suggesting that these genes might be induced in the inflamed synovium.
CXCL13 Binding (microarrays) of in synovium associated with chemokine and rheumatoid arthritis
1) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.18 Pain Relevance 0.95
Our observation of elevated CSF CXCL13 in CIS patients with presence of OCB and positive MRZR (Figure 2) demonstrates the association of CXCL13 with the polyspecific intrathecal B cell response in MS, which was suggested to derive from long-lived plasma cells in an enhanced B cell-promoting environment [7].
CXCL13 Binding (association) of in B cell associated with multiple sclerosis, syndrome and intrathecal
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.12 Pain Relevance 0.62
Both, CSF CxCL-13 levels and CxCL-13 CSF?
CxCL-13 Binding (Both) of
3) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.26 Pain Relevance 0.34
OA osteoblasts release more IL-6, CXCL12, CXCL13 and leptin that can also directly modulate COLLI synthesis, promote articular cartilage degradation and contribute to inflammatory state observed in OA.
CXCL13 Binding (more) of in articular cartilage associated with inflammation and osteoarthritis
4) Confidence 0.13 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656961 Disease Relevance 0.91 Pain Relevance 0.29
Barone et al. showed that, within salivary glands with lymphoepithelial sialadenitis (LESA) and MALT lymphoma, the lymphoid CKs CXCL13 and CCL21 are selectively associated with areas of reactive lymphoid proliferation, whereas no significant expression of these molecules was detected in the malignant lymphoid aggregate.
CXCL13 Binding (associated) of in MALT associated with chemokine, malignant neoplastic disease, lymphatic system cancer, salivary gland disease and sialadenitis
5) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.85 Pain Relevance 0.18

General Comments

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