INT182259

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (EDN1, TIMP1) extracellular space (EDN1) aging (TIMP1)
cell-cell signaling (EDN1) cytoplasm (EDN1)
Anatomy Link Frequency
chondrocytes 2
EDN1 (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 94.32 High High
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 36 100.00 Very High Very High Very High
Stress 3 74.80 Quite High
Apoptosis 14 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production

The mechanism of endothelin-1 (ET-1)-induced nitric oxide (NO) production, MMP-1 production and MMP-13 production was investigated in human osteoarthritis chondrocytes.

Endothelin-1 Positive_regulation (upregulates) of Gene_expression (production) of collagenase in chondrocytes associated with osteoarthritis
1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1065327 Disease Relevance 0.27 Pain Relevance 0.05

General Comments

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