INT182261

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (EDN1, MMP1) peptidase activity (MMP1) extracellular space (EDN1)
proteinaceous extracellular matrix (MMP1) cell-cell signaling (EDN1) cytoplasm (EDN1)
Anatomy Link Frequency
chondrocytes 2
EDN1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 105 99.70 Very High Very High Very High
metalloproteinase 3 81.08 Quite High
cytokine 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 108 99.70 Very High Very High Very High
Apoptosis 42 77.32 Quite High
Stress 9 72.28 Quite High
Death 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Osteoporosis 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Rheumatic Diseases 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of ET-1, protein kinase inhibitors and a guanylate cyclase inhibitor (LY83583) on MMP-1, MMP-13 and NO production
ET-1 Regulation (effect) of Gene_expression (production) of MMP-1
1) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0.04
In human osteoarthritis chondrocytes, ET-1 controls the production of MMP-1 and MMP-13.
ET-1 Regulation (controls) of Gene_expression (production) of MMP-1 in chondrocytes associated with osteoarthritis
2) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065327 Disease Relevance 0.30 Pain Relevance 0.08
The effects of ET-1 and those of various inhibitors on MMP-1 production and MMP-13 production are shown in Fig. 1.
ET-1 Regulation (effects) of Gene_expression (production) of MMP-1
3) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.40 Pain Relevance 0.03

General Comments

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