INT182262

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EDN1, NOS2) intracellular (NOS2) cell-cell signaling (EDN1)
cytosol (NOS2) extracellular space (EDN1) extracellular region (EDN1)
Anatomy Link Frequency
chondrocytes 2
EDN1 (Homo sapiens)
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 70 98.48 Very High Very High Very High
cytokine 6 96.24 Very High Very High Very High
rheumatoid arthritis 6 83.76 Quite High
metalloproteinase 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 72 98.48 Very High Very High Very High
Rheumatic Diseases 2 96.80 Very High Very High Very High
Stress 6 94.76 High High
Rheumatoid Arthritis 6 83.76 Quite High
Apoptosis 28 23.96 Low Low
Death 8 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteoporosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results show that ET-1 greatly increased MMP-1 and MMP-13 production, iNOS expression and NO release.
ET-1 Neg (NO) Positive_regulation (increased) of Gene_expression (expression) of iNOS
1) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065327 Disease Relevance 0.31 Pain Relevance 0.07
ET-1-induced stimulation of MMP-1 and MMP-13, as well as the induction of iNOS gene expression with subsequent NO overproduction by OA chondrocytes, may interfere with the proinflammatory cytokine pathways.
ET-1-induced Positive_regulation (induction) of Gene_expression (expression) of iNOS in chondrocytes associated with osteoarthritis and cytokine
2) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.48 Pain Relevance 0.24

General Comments

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