INT182264

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EDN1, MAPK14) nucleoplasm (MAPK14) response to stress (MAPK14)
cell-cell signaling (EDN1) cytosol (MAPK14) signal transduction (MAPK14)
Anatomy Link Frequency
chondrocytes 2
EDN1 (Homo sapiens)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 99.70 Very High Very High Very High
cytokine 3 27.72 Quite Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 36 99.70 Very High Very High Very High
Rheumatic Diseases 1 16.68 Low Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In OA chondrocytes, ET-1 seems to stimulate the production of these enzymes through activation of, at least, two kinases, p38 MAP kinase and PKA.
ET-1 Positive_regulation (stimulate) of Positive_regulation (activation) of p38 MAP in chondrocytes associated with osteoarthritis
1) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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