INT182265

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EDN1, NOS2) intracellular (NOS2) cell-cell signaling (EDN1)
cytosol (NOS2) extracellular space (EDN1) extracellular region (EDN1)
Anatomy Link Frequency
chondrocytes 1
EDN1 (Homo sapiens)
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 70 98.16 Very High Very High Very High
cytokine 6 94.56 High High
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 72 98.16 Very High Very High Very High
Osteoporosis 2 76.44 Quite High
Stress 6 70.28 Quite High
Apoptosis 28 32.00 Quite Low
Death 8 14.24 Low Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Rheumatic Diseases 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ET-1 also induces NO release via iNOS induction.
ET-1 Positive_regulation (induction) of iNOS
1) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065327 Disease Relevance 0.29 Pain Relevance 0.07
Our results suggest that the activation of PKA is also required for the ET-1-induced upregulation of iNOS and for subsequent production of NO by human OA chondrocytes.
ET-1-induced Positive_regulation (upregulation) of iNOS in chondrocytes associated with osteoarthritis
2) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.27 Pain Relevance 0.14

General Comments

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