INT182270

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (EDN1, MMP1) peptidase activity (MMP1) extracellular space (EDN1)
proteinaceous extracellular matrix (MMP1) cell-cell signaling (EDN1) cytoplasm (EDN1)
EDN1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 70 78.32 Quite High
cytokine 6 35.76 Quite Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 28 79.12 Quite High
Osteoarthritis 72 78.32 Quite High
Stress 6 29.72 Quite Low
Death 8 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteoporosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Rheumatic Diseases 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of these kinases is probably necessary for the induction by ET-1 of MMP-1 production and MMP-13 production.
ET-1 Positive_regulation (induction) of Gene_expression (production) of MMP-1
1) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.14 Pain Relevance 0.07
ET-1 induces MMP-1 and MMP-13 production
ET-1 Positive_regulation (induces) of Gene_expression (production) of MMP-1
2) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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