INT182271

Context Info Confidence 0.27 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.19

extracellular space (EDN1, MMP13) extracellular region (EDN1, MMP13) Golgi apparatus (MMP13) cell-cell signaling (EDN1) cytoplasm (EDN1) peptidase activity (MMP13)

EDN1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 35 95.28 Inflammation 1 88.08 Pain 1 27.40 rheumatoid arthritis 3 23.16 cytokine 3 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 36 95.28 INFLAMMATION 1 88.08 Disease 1 83.76 Pain 1 27.40 Rheumatoid Arthritis 3 23.16 Apoptosis 14 5.00 Death 4 5.00 Stress 3 5.00 Osteoporosis 1 5.00 Rheumatic Diseases 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Among all the MMPs, we have recently demonstrated an induction in the synthesis, secretion and activation of two collagenases (MMP-1 and MMP-13) by ET-1 [2].

ET-1 Positive_regulation (induction) of Localization (secretion) of MMP-13

1) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.47 Pain Relevance 0.19

General Comments

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