INT182272

Context Info Confidence 0.26 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.87 Pain Relevance 0.22

extracellular space (EDN1, MMP13) extracellular region (EDN1, MMP13) Golgi apparatus (MMP13) cell-cell signaling (EDN1) cytoplasm (EDN1) peptidase activity (MMP13)

EDN1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 105 83.68 metalloproteinase 3 81.08 cytokine 9 75.00 rheumatoid arthritis 9 5.00 Inflammation 3 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 108 83.68 Apoptosis 42 77.32 Osteoporosis 3 56.88 Death 12 53.52 Stress 9 27.92 Rheumatoid Arthritis 9 5.00 Pain 3 5.00 Disease 3 5.00 Rheumatic Diseases 3 5.00 INFLAMMATION 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effect of ET-1, protein kinase inhibitors and a guanylate cyclase inhibitor (LY83583) on MMP-1, MMP-13 and NO production

ET-1 Regulation (effect) of Gene_expression (production) of MMP-13

1) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0.04

The effect of ET-1 on MMP-13 production was more sensitive to the inhibitors of protein kinases than on MMP-1 production.

ET-1 Regulation (effect) of Gene_expression (production) of MMP-13

2) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.47 Pain Relevance 0.15

The effects of ET-1 and those of various inhibitors on MMP-1 production and MMP-13 production are shown in Fig. 1.

ET-1 Regulation (effects) of Gene_expression (production) of MMP-13

3) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.40 Pain Relevance 0.03

General Comments

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