INT182273

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EDN1, BAD) lipid binding (BAD) cytosol (BAD)
mitochondrion (BAD) extracellular space (EDN1) extracellular region (EDN1)
Anatomy Link Frequency
chondrocytes 2
EDN1 (Homo sapiens)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 97.76 Very High Very High Very High
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 14 100.00 Very High Very High Very High
Osteoarthritis 36 97.76 Very High Very High Very High
Death 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OA chondrocytes incubated in the absence of (control) or in the presence of ET-1 (10 nM) for 72 hours showed that ET-1 did not affect apoptosis (TUNEL reaction; data not shown) or the production of either anti-apoptotic Bcl2 or pro-apoptotic Bad proteins.
ET-1 Neg (not) Regulation (affect) of Gene_expression (production) of Bad in chondrocytes associated with apoptosis and osteoarthritis
1) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.73 Pain Relevance 0.12

General Comments

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