INT182274

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MAPK14, EDN1) nucleoplasm (MAPK14) cell-cell signaling (EDN1)
response to stress (MAPK14) cytosol (MAPK14) signal transduction (MAPK14)
MAPK14 (Homo sapiens)
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 84.32 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 36 84.32 Quite High
Stress 3 84.04 Quite High
Apoptosis 14 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the ET-1-induced NO production was partially suppressed by the p38 kinase inhibitor and was completely suppressed by the protein kinase A kinase inhibitor KT5720 and by LY83583, suggesting the involvement of these enzymes in relevant ET-1 signalling pathways.
p38 kinase Negative_regulation (suppressed) of Gene_expression (production) of ET-1-induced
1) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065327 Disease Relevance 0.31 Pain Relevance 0.07

General Comments

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